Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men

Ewelina Maculewicz; Andrzej Mastalerz; Agnieszka Maciejewska-Skrendo; Paweł Cięszczyk; Anna Cywińska; Anna Borecka; Aleksandra Garbacz; Ewa Szarska; Łukasz Dziuda; Katarzyna Lorenz; Roman Łakomy; Tomasz Lepionka; Anna Anyżewska; Agnieszka Białek; Jerzy Bertrandt

doi:10.5114/biolsport.2022.109957

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

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4/2021
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abstract:

Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men

Ewelina Maculewicz

¹

,

Andrzej Mastalerz

¹

,

Agnieszka Maciejewska-Skrendo

²

,

Paweł Cięszczyk

²

,

Anna Cywińska

³

,

Anna Borecka

⁴

,

Aleksandra Garbacz

⁵

,

Ewa Szarska

⁴

,

Łukasz Dziuda

⁶

,

Katarzyna Lorenz

¹

,

Roman Łakomy

⁴

,

Tomasz Lepionka

⁴

,

Anna Anyżewska

⁴

,

Agnieszka Białek

⁷

,

Jerzy Bertrandt

⁸

Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
Warsaw University of Life Sciences - SGGW, 02-787 Warsaw, Poland
Military Institute of Aviation Medicine, Warszawa, 01-755, Poland
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Magdalenka, Poland
Faculty of Health Sciences. Pope John Paul II State School of Higher Education in Biała Podlaska, 21-500 Biała Podlaska, Poland

Biol Sport. 2021;38(4):767–776

DOI: https://doi.org/10.5114/biolsport.2022.109957

Online publish date: 2021/12/28

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AMA

Maculewicz E, Mastalerz A, Maciejewska-Skrendo A, et al. Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport. 2021;38(4):767-776. doi:10.5114/biolsport.2022.109957.

APA

Maculewicz, E., Mastalerz, A., Maciejewska-Skrendo, A., Cięszczyk, P., Cywińska, A.,  & Borecka, A. et al. (2021). Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport, 38(4), 767-776. https://doi.org/10.5114/biolsport.2022.109957

Chicago

Maculewicz, Ewelina, Andrzej Mastalerz, Agnieszka Maciejewska-Skrendo, Paweł Cięszczyk, Anna Cywińska, Anna Borecka,  and Aleksandra Garbacz et al. 2021. "Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men". Biology of Sport 38 (4): 767-776. doi:10.5114/biolsport.2022.109957.

Harvard

Maculewicz, E., Mastalerz, A., Maciejewska-Skrendo, A., Cięszczyk, P., Cywińska, A., Borecka, A., Garbacz, A., Szarska, E., Dziuda, Ł., Lorenz, K., Łakomy, R., Lepionka, T., Anyżewska, A., Białek, A.,  and Bertrandt, J. (2021). Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport, 38(4), pp.767-776. https://doi.org/10.5114/biolsport.2022.109957

MLA

Maculewicz, Ewelina et al. "Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men." Biology of Sport, vol. 38, no. 4, 2021, pp. 767-776. doi:10.5114/biolsport.2022.109957.

Vancouver

Maculewicz E, Mastalerz A, Maciejewska-Skrendo A, Cięszczyk P, Cywińska A, Borecka A et al. Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport. 2021;38(4):767-776. doi:10.5114/biolsport.2022.109957.

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Peroxisome proliferator-activated receptors (PPARs) have unique functions in energy metabolism regulation but are also involved in regulation of the inflammatory process and obesity. The aim of this study was to analyse potential associations between polymorphisms of PPARA (rs1800206), PPARD (rs1053049; rs2267668) and PPARG (rs1801282) and overweight parameters. One hundred and sixty-six males, unrelated Caucasian military professionals, were recruited in the genetic case-control study conducted in the period 2016–2019. All the participants were aged 21–41 and had similar levels of physical activity. Body mass, height and body composition were measured. The participants were divided into two groups depending on their BMI (body mass index) and FMI (fat mass index). The control group consisted of people with BMI between 20.0 and 25.0 or FMI values ≤ 6, while the overweight group consisted of people with BMI of ≥ 25.0 or FMI values > 6. Genomic DNA was isolated from extracted buccal cells. All samples were genotyped using real-time polymerase chain reaction (real-time PCR). It was found that two polymorphisms rs2267668 and rs1053049 of the PPARD gene were significantly associated with BMI: SNP rs2267668 for the dominant (OR = 2.04, 95%CI 1.01–4.11, p-value = 0.04) model (A/G-G/G vs A/A). The likelihood of being overweight was over 2 times smaller for allele A. A relationship between the polymorphism of PPARG (rs1801282) and BMI was found for the overdominant (OR = 2.03, 95%CI 1.03–4.00, p-value = 0.04) model (C/G vs C/C-G/G). Significant associations were found in different models for PPARD, PPARG and PPARA genes with BMI. In SNP rs2267668 for the codominant genetic model (G/G vs A/A) (p-value = 0.04) and in SNP rs1053049 for the codominant (C/C vs T/T) (p-value = 0.01) and the recessive genetic model (C/C vs T/T–C/T) (p-value = 0.004) all polymorphisms were associated with BMI. In conclusion, it was found that three of the four polymorphisms (rs1053049, rs2267668, rs1801282) selected are associated with the risk of being overweight. Having said that, one has to bear in mind that DNA variants do not fully explain the reasons for being overweight. Therefore more research is needed to make a thorough assessment using the latest genomic methods in sequencing and genotyping, combined with epigenomics, proteomics, transcriptomics, and metabolomics.

keywords:

Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men

genetic polymorphisms, body mass index, fat mass, overweight, PPARA, PPARD, PPARG