Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men

Ewelina Maculewicz; Andrzej Mastalerz; Agnieszka Maciejewska-Skrendo; Paweł Cięszczyk; Anna Cywińska; Anna Borecka; Aleksandra Garbacz; Ewa Szarska; Łukasz Dziuda; Katarzyna Lorenz; Roman Łakomy; Tomasz Lepionka; Anna Anyżewska; Agnieszka Białek; Jerzy Bertrandt

doi:10.5114/biolsport.2022.109957

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

Current Issue Manuscripts accepted About the journal Editorial board Abstracting and indexing Archive Ethical standards and procedures Contact Instructions for authors Journal's Reviewers Special Information

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

4/2021
vol. 38

Send email

Copy url:

Ewelina Maculewicz

¹

,

Andrzej Mastalerz

¹

,

Agnieszka Maciejewska-Skrendo

²

,

Paweł Cięszczyk

²

,

Anna Cywińska

³

,

Anna Borecka

⁴

,

Aleksandra Garbacz

⁵

,

Ewa Szarska

⁴

,

Łukasz Dziuda

⁶

,

Katarzyna Lorenz

¹

,

Roman Łakomy

⁴

,

Tomasz Lepionka

⁴

,

Anna Anyżewska

⁴

,

Agnieszka Białek

⁷

,

Jerzy Bertrandt

⁸

Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
Warsaw University of Life Sciences - SGGW, 02-787 Warsaw, Poland
Military Institute of Aviation Medicine, Warszawa, 01-755, Poland
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Magdalenka, Poland
Faculty of Health Sciences. Pope John Paul II State School of Higher Education in Biała Podlaska, 21-500 Biała Podlaska, Poland

Biol Sport. 2021;38(4):767–776

DOI: https://doi.org/10.5114/biolsport.2022.109957

Online publish date: 2021/12/28

Article file

- 32_PPARD_Article.pdf [0.36 MB]

Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Maculewicz E, Mastalerz A, Maciejewska-Skrendo A, et al. Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport. 2021;38(4):767-776. doi:10.5114/biolsport.2022.109957.

APA

Maculewicz, E., Mastalerz, A., Maciejewska-Skrendo, A., Cięszczyk, P., Cywińska, A.,  & Borecka, A. et al. (2021). Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport, 38(4), 767-776. https://doi.org/10.5114/biolsport.2022.109957

Chicago

Maculewicz, Ewelina, Andrzej Mastalerz, Agnieszka Maciejewska-Skrendo, Paweł Cięszczyk, Anna Cywińska, Anna Borecka,  and Aleksandra Garbacz et al. 2021. "Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men". Biology of Sport 38 (4): 767-776. doi:10.5114/biolsport.2022.109957.

Harvard

Maculewicz, E., Mastalerz, A., Maciejewska-Skrendo, A., Cięszczyk, P., Cywińska, A., Borecka, A., Garbacz, A., Szarska, E., Dziuda, Ł., Lorenz, K., Łakomy, R., Lepionka, T., Anyżewska, A., Białek, A.,  and Bertrandt, J. (2021). Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport, 38(4), pp.767-776. https://doi.org/10.5114/biolsport.2022.109957

MLA

Maculewicz, Ewelina et al. "Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men." Biology of Sport, vol. 38, no. 4, 2021, pp. 767-776. doi:10.5114/biolsport.2022.109957.

Vancouver

Maculewicz E, Mastalerz A, Maciejewska-Skrendo A, Cięszczyk P, Cywińska A, Borecka A et al. Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men. Biology of Sport. 2021;38(4):767-776. doi:10.5114/biolsport.2022.109957.

PlumX metrics:

1. Agha M, Agha R. The rising prevalence of obesity: part A: impact on public health. Int J Surg Oncol. 2017;2:e17, doi:10.1097/ij9.0000000000000017.

2. Stienstra R, Duval C, Műller M, Kersten S. PPARs, Obesity, and Inflammation. PPAR Res. 2007; doi:10.1155/2007/95974.

3. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology. 1996; 137:354–366.

4. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzales FJ, Grimaldi PA, Kadowaki T, Lazar MA, O’Rahilly S, Palmer CAN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International union of pharmacology. LXI. Peroxisome proliferatoractivated receptors. Pharmacol Rev. 2006; 58:726–741.

5. Nuclear Receptors Nomenclature Committee. A unified nomenclature system for the nuclear receptor superfamily. Cell. 1999; 97:1–3.

6. Maciejewska-Karwowska A. Polymorphic variants of the PPAR (Peroxisome Proliferator-Activated Receptor) genes: relevance for athletic performance. Trends Sport Sci 2013; 1(20):5–15.

7. Luo W, Guo Z, Wu M, Hao Ch, Hu X, Zhou Z, Zhou Z, Yao X, Zhang L, Jingchao L. Association of Peroxisome Proliferator-Activated Receptor α/δ/γ With Obesity, and Gene–Gene Interaction, in the Chinese Han Population. J Epidemiol. 2013; doi:10.2188/jea.JE20120110

8. Mandard S, Müller, Kersten S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci. 2004;61(4):393–416.

9. Kersten S. Integrated physiology and systems biology of PPARα. Mol Metab. 2014;3:354-371.

10. Grarup N, Albrechtsen A, Ek J, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O. Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middleaged white people. Diabetologia. 2007; 50(6):1201–1208.

11. Seedorf U, Aberle J. Emerging roles of PPARdelta in metabolism. Biochim Biophys Acta. 2007; 1771(9):1125–1131.

12. Lehrke M, Lazar M. The Many Faces of PPARγ. Cell. 2005; 123:993–999.

13. WHO. Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation; WHO Technical Report Series 894; WHO: Geneva, Switzerland. 2000; pp. 1–253.

14. Kelly T, Wilson W, Heymsfield B. Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES. PLOS ONE. 2009; 4, e7038

15. R Foundation for Statistics Computing, https://cran.r-project.org, version 2.0-1

16. Bastard J, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Net. 2006; 17(1):4–12.

17. Balistreri C, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediat Inflamm. 2010; 19, doi:10.1155/2010/802078.

18. Goni L, García-Granero M, Milagro FI, Cuervo M, Martínez JA. Phenotype and genotype predictors of BMI variability among European adults. Nutr Diabetes. 2018;8:27, DOI 10.1038/s41387-018- 0041-1

19. Bosse Y, Despre´s JP, Bouchard C, Pe´russe L, Vohl MC. The Peroxisome Proliferator-Activated Receptor alpha L162V Mutation Is Associated with Reduced Adiposity. Obes Res. 2003; 11:809–816.

20. Silbernagel G, Stefan N, Hoffmann MM, Machicao-Arano F, Machann J, Schick F, Winkelmann B, Boehm B, Häring H, Fritsche A, März W. The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition. Exp Clin Endocrinol Diabetes. 2009; 117:113–118.

21. Evans D, Aberle J, Wendt D, Wolf A, Beisiegel U, Mann W. A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPARα) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus. J Mol Med. 2001; 79:198–204.

22. Andrulionyte L, Kuulasmaa T, Chiasson JL, Laakso M. Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-Alpha Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes The STOP-NIDDM Trial. Diabetes. 2007; 56:1181–1186.

23. Tai E, Demissie S, Cupples L, Corella D, Wilson P, Schaefer E, Ordovas J. Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels. The Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 2002; 22:805–810.

24. Aberle J, Hopfer I, Beil FU, Seedorf U. Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. Int J Obes. 2006; 30:1709–1713.

25. Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen K, Lautamäki R, Peltoniemi P, Takala T, Viljanen A, Knuuti J, Laakso M. Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake. Diabetes. 2005;54:3587–3591.

26. Thamer C, Machann J, Stefan N, Schafer S, Machicao F, Staiger H, Laakso M, Böttcher M, Claussen C, Schick F, Fritsche A, Haring HU. Variations in PPARD Determine the Change in Body Composition during Lifestyle Intervention: A Whole-Body Magnetic Resonance Study. J Clin Endocrinol Metab. 2008; 93(4):1497–1500.

27. Villegas R, Williams S, Gao Y, Cai Q, Li H, Elasy T, Cai H, Edwards T, Xiang YB, Zheng W, Long J, Shu XO. Peroxisome proliferator-activated receptor (PPAR) delta genetic variation and type 2 diabetes in middle age Chinese women. Ann Hum Genet. 2011; 75(5):621–629.

28. Shin HD, Park BL, Kim LH, Jung HS, Cho YM, Moon MK, Park YJ, Lee HK, Park KS. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Diabetes. 2004; 53(3):847–851.

29. Leońska-Duniec A, Cięszczyk P, Jastrzębski Z, Jażdżewska A, Lulińska-Kuklik E, Moska W, Ficek K, Niewczas M, Maciejewska-Skrendo A. The polymorphisms of the PPARD gene modify post-training body mass and biochemical parameter changes in women. PLoS ONE. 2018; 13(8): e0202557

30. Bordoni L, Marchegiani F, Piangerelli M, Napolioni V, Gabbianelli R. Obesity-Related Genetic Polymorphisms and Adiposity Indices in a Young Italian Population. IUBMB. 2017; 69(2):98–105 DOI 10.1002/iub.1596

31. dos Santos Rodrigues AP, Rosa LP, da Silva HD, de Paula Silveira-Lacerda E, Silveira EA. The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. J Obesity. 2018; https://doi. org/10.1155/2018/ 2743081

32. Chan KH, Niu T, Ma Y, You NY, Song Y, Sobel EM, Hsu Y, Balasubramanian R, Qiao Y, Tinker L, Liu S. Common Genetic Variants in Peroxisome Proliferator Activated Receptor-γ (PPARG) and Type 2 Diabetes Risk Among Women’s Health Initiative Postmenopausal Women. J Clin Endocrinol Metab. 2013; 98(3):E600–E604.

33. Hasan NS, Kamel SA, Hamed M, Awadallah E, Rahman EH, Musa NI, Hussein GH. Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus. J Genet Eng Biotechnol. 2017; 15:409–414.

34. Kruzliak P, Haley AP, Starcevic JN, Gaspar L, and Petrovic D. Polymorphisms of the Peroxisome Proliferator-Activated Receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus. Cardiovasc Diabetol. 2015; 14:42

35. Rocha RM, Barra GB, Campos Caldas Rosa EC, Garcia EC, Amorim Amato A, Ferreira Azevedo M. Prevalence of the rs1801282 single nucleotide polymorphism of the PPARG gene in patients with metabolic syndrome. Arch Endocrinol Metab. 2015; 59/4.

36. Tellechea ML, Aranguren F, Pérez MS, Cerrone GE, Frechtel GD, Taverna MJ. Pro12Ala polymorphism of the peroxisome proliferator activated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status. Circ J. 2009; 73:2118–2124.

37. Leońska-Duniec A, Ahmetov Il, Żmijewski P. Genetic variants influencing effectiveness of exercise training programmes in obesity – an overview of human studies. Biol Sport. 2016; 33(3):207–214.

Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.