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Polish Journal of Pathology
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Original paper

Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer

Gizem Teoman
1
,
Zeynep Turkmen Usta
1
,
Zeynep Sagnak Yilmaz
1
,
Sevdegul Aydin Mungan
1
,
Ismail Saygin
1

  1. Karadeniz Technical University, Faculty of Medicine, Department of Pathology, Trabzon, Turkey
Pol J Pathol 2024; 75 (4):
DOI: https://doi.org/10.5114/pjp.2024.145702
Online publish date: 2024/12/05
Article file
- Association (1).pdf  [0.15 MB]
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1. Aoki M, Fujishita T. Oncogenic roles of the PI3K/Akt/mTOR axis. Curr Top Microbiol Immunol 2017; 407: 153-189.
2. Follo MY, Manzoli L, Poli A, et al. PLC and PI3K/Akt/mTOR signalling in disease and cancer. Adv Biol Regul 2015; 57: 10-16.
3. Tserga A, Chatziandreou I, Michalopoulos NV, et al. Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness. Virchows Arch 2016; 469: 35-43.
4. Fan H, Li C, Xiang Q, et al. PIK3CA mutations and their response to neoadjuvant treatment in early breast cancer: a systematic review and meta-analysis. Thorac Cancer 2018; 9: 571-579.
5. Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Biol 2007; 13: 408-415.
6. Sudhakar N, George PDC, Thirumal KD, et al. Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach. J Biomol Struct Dyn 2015; 34: 29-41.
7. Dirican E, Seven İ, Kaya H, et al. PIK3CA and TP53 mutations and SALL4, PTEN and PIK3R1 gene expression levels in breast cancer. Turk J Biochem 2020; 45: 515-523.
8. Martinez-Saez O, Chic N, Pascual T, et al. Frequency and spectrum of PIK3CA somatic mutations in breast cancer. Breast Cancer Res 2020; 22: 45. DOI: 10.1186/s13058-020-01284-9.
9. Vasan N, Razavi P, Johnson JL, et al. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Ka inhibitors. Science 2019; 366: 714-723.
10. Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J Pathol 2006; 208: 350-355.
11. Aleskandarany MA, Rakha EA, Ahmed MA, et al. PIK3CA expression in invasive breast cancer: a biomarker of poor prognosis. Breast Cancer Res Treat 2010; 122: 45-53.
12. Lian J, Xu EW, Xi YF, et al. Clinical-pathologic analysis of breast cancer with PIK3CA mutations in Chinese women. Technol Cancer Res Treat 2020; 19: 1533033820950832. DOI: 10.1177/1533033820950832.
13. Reinhardt K, Stückrath K, Hartung C, et al. PIK3CA-mutations in breast cancer. Breast Cancer Res Treat 2022; 196: 483-493.
14. Campbell RA, Bhat-Nakshatri P, Patel NM, et al. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 2001; 276: 9817-9824.
15. Dong C, Wu J, Chen Y, et al. Activation of PI3K/AKT/ mTOR pathway causes drug resistance in breast cancer. Front Pharmacol 2021; 12: 628690. DOI: 10.3389/fphar.2021.628690.
Copyright: © 2024 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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