eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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3/2020
vol. 17
 
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abstract:
Review paper

Association of uromodulin with acute kidney injury in patients undergoing cardiac surgery

Dariusz Chojęta
1
,
Małgorzata M. Kozioł
2
,
Sylwia Targońska
3
,
Iwona Smarz-Widelska
4

  1. Students Scientific Association at the Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, Poland
  2. Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, Poland
  3. Department of Cardiac Surgery, Medical University of Lublin, Lublin, Poland
  4. Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital, Lublin, Poland
Kardiochir Torakochir Pol 2020; 17 (3): 160-164
DOI: https://doi.org/10.5114/kitp.2020.99081
Online publish date: 2020/09/23
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Uromodulin (Umod) is a protein produced exclusively in the kidneys, and it is the most abundant protein in human urine. Scientific studies show that it can be a valuable diagnostic tool in monitoring kidney function. Clinical applications of Umod are probably wider. One of them is the role of a biomarker in cardiac surgery-associated acute kidney injury (CSA-AKI). Data from scientific studies indicate that a lower level of Umod in urine prior to surgery is associated with a higher risk of developing CSA-AKI after the procedure. A higher serum Umod level is suspected to be a good prognostic factor in the context of renal healing. It seems that the current state of knowledge supports the protective role of Umod in the course of AKI. Large, multi-center clinical trials would allow for the consolidation of preliminary scientific data and a more accurate understanding of the role of Umod as a CSA-AKI biomarker.
keywords:

uromodulin, Tamm-Horsfall protein, cardiac surgery-associated acute kidney injury, kidney disease
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