Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population

Yiping Ma; Zhi Xiang; Xu Yao; Chengrang Li; Jianbing Wu; Suying Feng; Pangen Cui; Lin Lin

doi:10.5114/ada.2020.94843

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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2/2020
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Original paper

Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population

Yiping Ma

¹

,

Zhi Xiang

¹

,

Xu Yao

¹

,

Chengrang Li

¹

,

Jianbing Wu

¹

,

Suying Feng

¹

,

Pangen Cui

¹

,

Lin Lin

¹

Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China

Adv Dermatol Allergol 2020; XXXVII (2): 250–254

DOI: https://doi.org/10.5114/ada.2020.94843

Online publish date: 2020/05/06

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AMA

Ma Y, Xiang Z, Yao X, et al. Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):250-254. doi:10.5114/ada.2020.94843.

APA

Ma, Y., Xiang, Z., Yao, X., Li, C., Wu, J.,  & Feng, S. et al. (2020). Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), 250-254. https://doi.org/10.5114/ada.2020.94843

Chicago

Ma, Yiping, Zhi Xiang, Xu Yao, Chengrang Li, Jianbing Wu, Suying Feng,  and Pangen Cui et al. 2020. "Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (2): 250-254. doi:10.5114/ada.2020.94843.

Harvard

Ma, Y., Xiang, Z., Yao, X., Li, C., Wu, J., Feng, S., Cui, P.,  and Lin, L. (2020). Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), pp.250-254. https://doi.org/10.5114/ada.2020.94843

MLA

Ma, Yiping et al. "Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 2, 2020, pp. 250-254. doi:10.5114/ada.2020.94843.

Vancouver

Ma Y, Xiang Z, Yao X, Li C, Wu J, Feng S et al. Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):250-254. doi:10.5114/ada.2020.94843.

Introduction
Previous studies found that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with several inflammatory diseases. However, the relationship between VDR gene polymorphisms and chronic spontaneous urticaria (CSU) is not clear.

Aim
The purpose of our study was to explore the relationship between the polymorphism of VDR and the incidence of chronic spontaneous urticaria in the Chinese Han population. Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected.

Material and methods
The genotypes of four VDR polymorphisms (TaqI, BsmI, ApaI, and FokI) were studied using allele-speciﬁc PCR analysis in 90 CSU patients and 90 healthy controls.

Results
Compared to the control group, the mutant allele (C) of FokI were more common in patients with CSU (57.2% vs. 45%, p = 0.020, odds ratio (OR) = 0.612, 95% confidence interval (CI): 0.403–0.928). We found that serum vitamin D levels were significantly lower in CSU patients than in healthy controls (p = 0.023). However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU.

Conclusions
We first reported the effect of VDR gene FokI (rs2228570) polymorphism on the incidence of chronic spontaneous urticaria in the Chinese Han population.

keywords:

Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population

Yiping Ma 1 , Zhi Xiang 1 , Xu Yao 1 , Chengrang Li 1 , Jianbing Wu 1 , Suying Feng 1 , Pangen Cui 1 , Lin Lin 1

urticaria, vitamin D receptor, gene polymorphisms

Yiping Ma

¹

,

Zhi Xiang

¹

,

Xu Yao

¹

,

Chengrang Li

¹

,

Jianbing Wu

¹

,

Suying Feng

¹

,

Pangen Cui

¹

,

Lin Lin

¹