eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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4/2022
vol. 73
 
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abstract:
Case report

Atypical spindle cell lipomatous tumour presenting as a large retroperitoneal mass – a case report and review of the literature

Martyna Aleksandra Krupinska
1
,
Carmen Nieves Hernandez León
1
,
Rocío López Henríquez
1
,
Beatriz Esquivel Vázquez
1
,
Rosa Nieves Rodríguez Rodríguez
1
,
Patricia Marrero Marrero
2
,
Luciano Delgado Plasencia
2
,
Eduardo Salido
1

  1. Department of Pathology, University Hospital of the Canary Islands, University of La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
  2. Department of General and Digestive Surgery, University Hospital of the Canary Islands, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
Pol J Pathol 2022; 73 (4): 364-370
DOI: https://doi.org/10.5114/pjp.2022.125654
Online publish date: 2023/03/12
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Atypical spindle cell lipomatous tumour (ASCLT) is a benign neoplasm that presents a variable proportion of atypical spindle and adipocytic cells, frequently expressing CD34, and embedded in myxoid or collagenous matrix. An important feature is a constant lack of either MDM2 or CDK4 amplification. It typically arises in the extremities. The retroperitoneum is a rare site of involvement. We report a case of a retroperitoneal ASCLT in a 62-year-old male. A differential diagnosis of ASCLT from the other mesenchymal, spindle-cell, and lipomatous tumours is crucial for optimal treatment and significantly influences the prognosis. A diagnosis should be warranted by the immunohistochemistry and molecular findings.
keywords:

lipomatous, spindle cell, neoplasm, retroperitoneal, RB1 deletion
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