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ISSN: 0031-3939
Pediatria Polska - Polish Journal of Paediatrics
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3/2023
vol. 98
 
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abstract:
Review paper

Autoimmune hepatitis and primary sclerosing cholangitis overlap syndrome in inflammatory bowel diseases

Joanna Saganek
1
,
Monika Meglicka
1
,
Aleksandra Nowakowska
1
,
Marcin Osiecki
1
,
Jarosław Kierkuś
1

  1. Department of Gastroenterology, Hepatology, Feeding Disorders, and Paediatrics, The Children’s Memorial Health Institute, Warsaw, Poland
Pediatr Pol 2023; 98 (3): 236-241
DOI: https://doi.org/10.5114/polp.2023.131762
Online publish date: 2023/09/29
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A close relationship between inflammatory bowel diseases (IBD) and hepatobiliary disorders, such as autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC), is well established. Hepatobiliary manifestations occur in 30% of patients with IBD, and 5% develop chronic liver disease. The spectrum of symptoms of the overlap syndrome ranges from asymptomatic elevated liver function tests to serious diseases. The pathogenesis of liver complications in IBD is not fully recognized. It may either have an autoimmune background or be caused by intestinal inflammation, metabolic impairment, or drug toxicity. The aim of this review is to summarize AIH and PSC overlap syndrome in IBD.
keywords:

inflammatory bowel disease, autoimmune hepatitis, overlap syndrome, primary sclerosing cholangitis