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2/2022
vol. 97 abstract:
Case report
Autoimmune polyglandular syndrome type 2 in an 15-year-old boy
Andrzej Badeński
1
,
Marta Badeńska
2
,
Magdalena Mierzwa
3
,
Małgorzata Stojewska
1
,
Grażyna Deja
4
,
Maria Szczepańska
1
,
Katarzyna Ziora
1
Pediatr Pol 2022; 97 (2): 151-155
Online publish date: 2022/06/10
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Autoimmune polyendocrine syndromes (APS) include a diverse group of clinical conditions, characterized by functional impairment of many endocrine glands. Type 2 APS is characterized by the mandatory presence of Addison’s disease, which may be associated with either autoimmune thyroid diseases as a Schmidt’s syndrome or type 1 diabetes mellitus as a Carpenter syndrome.
The described patient with well-controlled diabetes mellitus type 1, presented with sudden, frequent episodes of hypoglycemia, daytime somnolence and weariness, as well as remarkable hyperpigmentation of the skin. Laboratory tests revealed adrenal insufficiency with a positive titer of anti-adrenal antibodies, which led to APS-2 diagnosis in the presented case. As the clinical outcome at the early onset of the APS-2 is not distinctive, the authors would like to emphasize the significance of screening methods, especially in patients with other hormone abnormalities, to protect them from the consequences of life-threatening disturbances. keywords:
Addison’s disease, diabetes mellitus type 1, autoimmune polyglandular syndrome, rare diseases, carpenter syndrome |