Autologous stem cell transplantation for mantle cell lymphoma – single centre experience

Magdalena Szcześniak; Anna Armatys; Rafał Kurzawa; Tomasz Kandzia; Dominika Kozioł; Andrzej Frankiewicz; Anna Kopińska; Małgorzata Krawczyk-Kuliś; Sławomira Kyrcz-Krzemień; Grzegorz Helbig

doi:10.5114/wo.2013.37223

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2013
vol. 17

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abstract:

Original paper

Autologous stem cell transplantation for mantle cell lymphoma – single centre experience

Magdalena Szcześniak

,

Anna Armatys

,

Rafał Kurzawa

,

Tomasz Kandzia

,

Dominika Kozioł

,

Andrzej Frankiewicz

,

Anna Kopińska

,

Małgorzata Krawczyk-Kuliś

,

Sławomira Kyrcz-Krzemień

,

Grzegorz Helbig

Contemp Oncol (Pozn) 2013; 17 (5): 456–459

DOI: https://doi.org/10.5114/wo.2013.37223

Online publish date: 2013/10/11

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Aim of the study: Mantle cell lymphoma (MCL) is a B-cell neoplasm showing resistance to conventional chemotherapy. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may result in higher progression-free (PFS) and overall survival (OS) when used as a consolidation for younger and fit patients.

Material and methods: We retrospectively evaluated the results of ASCT for MCL. Patients were transplanted after achieving first or subsequent complete or partial response after conventional chemotherapy.

Results: Twenty patients (7 male and 13 female) at median age of 59 years (range 41–68) were included. 90% of transplanted patients had stage III/IV disease at diagnosis and low, intermediate and high MIPI scores occurred in 5, 9 and 6 patients respectively. Induction chemotherapy consisted of the R-CHOP regimen in all patients except one who received R-CVAD. The disease status at transplant was as follows: first complete response (n = 13); second complete response (n = 4) and partial response (n = 3). The conditioning regimen prior to ASCT consisted of CBV and BEAM for 18 and 2 patients, respectively. The transplant-related mortality was 0% at day 100. Median OS and PFS were 48 and 29.8 months, respectively. The estimated 5-year OS and PFS were found to be 52% and 35%, respectively. After median follow-up after ASCT of 36 months (range 11–73), 10 patients were alive with 8 remaining in complete remission (CR) whereas 2 relapsed and received salvage chemotherapy. Ten patients died from disease recurrence and subsequent chemoresistance.

Conclusions: ASCT as a consolidation for MCL patients is found to be an effective and safe procedure.

keywords:

Autologous stem cell transplantation for mantle cell lymphoma – single centre experience

Magdalena Szcześniak , Anna Armatys , Rafał Kurzawa , Tomasz Kandzia , Dominika Kozioł , Andrzej Frankiewicz , Anna Kopińska , Małgorzata Krawczyk-Kuliś , Sławomira Kyrcz-Krzemień , Grzegorz Helbig

mantle cell lymphoma, autologous stem cell transplantation, results

Magdalena Szcześniak

,

Anna Armatys

,

Rafał Kurzawa

,

Tomasz Kandzia

,

Dominika Kozioł

,

Andrzej Frankiewicz

,

Anna Kopińska

,

Małgorzata Krawczyk-Kuliś

,

Sławomira Kyrcz-Krzemień

,

Grzegorz Helbig