Benzophenone-3, a chemical UV-filter in cosmetics:
is it really safe for children and pregnant women?

Weronika Wnuk; Klaudia Michalska; Anna Krupa; Krystyna Pawlak

doi:10.5114/ada.2022.113617

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women?

Weronika Wnuk

¹

,

Klaudia Michalska

¹

,

Anna Krupa

¹

,

Krystyna Pawlak

¹

Department of Monitored Pharmacotherapy, Medical University of Bialystok, Bialystok, Poland

Adv Dermatol Allergol 2022; XXXIX (1): 26-33

DOI: https://doi.org/10.5114/ada.2022.113617

Online publish date: 2022/02/28

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Children and adolescents are particularly vulnerable to skin damage caused by ultraviolet radiation and require intensified photoprotection. Benzophenone-3 (BP-3) belongs to the organic sunscreens, which are widely used in personal care and cosmetic products. However, the impact of BP-3 on human health requires a careful assessment. This review focuses on potentially harmful effect of this compound in relation to the developing organism. Studies show that BP-3, after topical application, can penetrate into bloodstream, blood-brain barrier and blood-placental barrier and may induce the reproductive toxicity and abnormal development of the foetus, endocrine system disruption and neurotoxicity in experimental animal models. So far, human studies have been scarce and controversial, therefore the cosmetics containing BP-3 should be carefully used by the pregnant women, children and adolescents.

keywords:

Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women?

Weronika Wnuk 1 , Klaudia Michalska 1 , Anna Krupa 1 , Krystyna Pawlak 1

benzophenone-3, cosmetics, developmental toxicity, endocrine disruption, neurotoxicity

Weronika Wnuk

¹

,

Klaudia Michalska

¹

,

Anna Krupa

¹

,

Krystyna Pawlak

¹