|
Current issue
Archive
Videos
Articles in press
About the journal
Supplements
Editorial board
Reviewers
Abstracting and indexing
Subscription
Contact
Instructions for authors
Publication charge
Ethical standards and procedures
Editorial System
Submit your Manuscript
|
3/2019
vol. 121 abstract:
Original paper
Biological Treatment of Chronic Non-infectious Uveitis in the Developmental Age
Anna Niwald
1
,
Mirosława Grałek
1
,
Katarzyna Piasecka
1
,
Ewa Lipiec
1
Online publish date: 2019/11/18
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
Aim
Evaluation of the results of treatment of chronic non-infectious uveitis with biologic agents in children and adolescents. Materials and Methods 8 children (5 girls, 3 boys) treated with biologics (Humira, Remicade) after previous treatment with first and second therapy lines drugs. Binocular changes were observed in 6 children, monocular changes in 2 children (14 eyes). For the diagnosis of non-infectious uveitis and to evaluate the effects of treatment, the ophthalmic examination and research of the laboratory diagnosis and imaging were used. The average time of biological treatment was 12.8 months. Results In the examined group of children the number of relapses of the disease (an average of 0.57) has decreased. Visual acuity has improved in every child (mean V = 0.79). Ocular complications occurred in 4 eyes, general complications in 3 children. Conclusions Biological therapy of non-infectious uveitis in children is not causal treatment indeed, focused on the ethological factors. However, it influences the patomechanism of disease, strongly modificating its course thus reducing this symptoms and easing this effects. keywords:
children, non-infectious uveitis, juvenile idiopathic arthritis, immunosuppression, biologic therapy, side effects |
|
POLSKI
