Biological and clinical impact of IL-6 production by ovarian carcinoma cells

Andrzej Lange; Ilona Kryczek; Marian Gryboś

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/1999
vol. 3

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abstract:

Biological and clinical impact of IL-6 production by ovarian carcinoma cells

Andrzej Lange

,

Ilona Kryczek

,

Marian Gryboś

Współcz Onkol (1999) 3 (5), 195-198

Online publish date: 2003/08/06

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In this review article some information is presented regarding of the biological impact of interleukin 6 (IL-6) production by ovarian carcinoma. This is illustrated by elevation of C-reactive protein (CRP) in sera of ovarian carcinoma patients and a fair degree correlation between ascites IL-6 levels and platelet count. IL-6 is physiologically produced by ovarian granulosa cells and this production is regulated by gonadotropin activity. In ovarian carcinoma patients IL-6 production is highly elevated and automonous. This is suggested by higher level of IL-6 generation in carcinomatous than in benign cysts. Ovarian cancer IL-6 generation is associated with tumour morphology; papillare cancers and mucous/serous tumours are good producers of IL-6. Ability of ovarian carcinoma cells to produce IL-6 likely reflects the level of differentiation of ovarian cell which is transformed to carcinoma cell. IL-6 and its reading protein CRP maybe regarded as markers of ovarian tumours with the potential to modulate local immunity.

keywords:

Biological and clinical impact of IL-6 production by ovarian carcinoma cells

Andrzej Lange , Ilona Kryczek , Marian Gryboś

ovarian carcinoma, IL-6, peritoneal fluid, CRP, memory cells, CD45RO

Andrzej Lange

,

Ilona Kryczek

,

Marian Gryboś