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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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5/2020
vol. 107
 
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abstract:
Special paper

Biological drugs in the treatment of atopic dermatitis – recommendations of the Polish Dermatological Society, the Polish Society of Allergology, the Polish Pediatric Society and the Polish Society of Family Medicine

Roman J. Nowicki
1
,
Magdalena Trzeciak
1
,
Lidia Rudnicka
2
,
Jacek Szepietowski
3
,
Marek Kulus
4
,
Maciej Kupczyk
5
,
Agnieszka Mastalerz-Migas
6
,
Jaroslaw Peregud-Pogorzelski
7
,
Karina Jahnz-Różyk
8
,
Joanna Narbutt
9
,
Magdalena Czarnecka-Operacz
10
,
Rafał Czajkowski
11
,
Elżbieta Grubska-Suchanek
1
,
Dorota Krasowska
12
,
Beata Kręcisz
13
,
Cezary Kowalewski
14
,
Aleksandra Lesiak
8
,
Małgorzata Olszewska
2
,
Zbigniew Samochocki
2
,
Radosław Śpiewak
15
,
Aleksandra Wilkowska
1

  1. Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
  2. Department of Dermatology, Medical University of Warsaw, Warsaw, Poland
  3. Department of Dermatology, Venereology and Allergology, Medical University of Wroclaw, Wroclaw, Poland
  4. Department of Pediatric Pneumonology and Allergology, Medical University of Warsaw, Warsaw, Poland
  5. Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
  6. Department of Family Medicine, Medical University of Wroclaw, Wroclaw, Poland
  7. Department of Pediatrics and Pediatric Oncology, Pomeranian Medical University, Szczecin, Poland
  8. Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Military Medical Institute, Warsaw, Poland
  9. Department of Dermatology, Pediatric and Oncological Dermatology, Medical University of Lodz, Poland
  10. Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
  11. Department of Dermatology and Venereology, “Ludwik Rydygier” Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  12. Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
  13. Department of Dermatology, The Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland
  14. Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland
  15. Department of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland
Dermatol Rev/Przegl Dermatol 2020, 107, 409–423
DOI: https://doi.org/10.5114/dr.2020.101669
Online publish date: 2020/12/29
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The basis for development of atopic dermatitis are genetic, immunological and microbiological abnormalities as well as epidermal barrier defects. The course of the disease includes periodic exacerbations and remissions. Its development and course are influenced by numerous environmental and individual factors. In recent decades, in industrialized countries, a threefold increase in the incidence of atopic dermatitis was observed. There also is an increasing number of cases resistant to topical treatment. Effective treatment of atopic dermatitis should provide control of clinical symptoms, prevent exacerbations and improve the quality of life of patients. The multifactorial etiopathogenesis and various endotypes and phenotypes of the disease justify the tendency to optimize and personalize the therapy. Currently, we recommend the use of dupilumab for the treatment of patients from 12 years of age with moderate and severe atopic dermatitis, who do not respond to topical treatment.
keywords:

biological drugs, dupilumab, atopic dermatitis, therapeutic recommendations
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