Biology of Sport
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Original paper

Brain-derived neurotrophic factor gene polymorphism rs6265 and elite athlete status in four independent populations

Gabija Anikevičiūtė
1
,
Alina Urnikytė
1
,
Myosotis Massidda
2
,
Carla Maria Calò
3
,
Filippo Tocco
2
,
Mizuki Takaragawa
4
,
Eri Miyamoto-Mikami
4
,
Haruka Murakami
5
,
Motohiko Miyachi
6
,
Noriyuki Fuku
4
,
Kinga Humińska-Lisowska
7
,
Kinga Łosińska
7
,
Pawel Cięszczyk
7
,
Valentina Ginevičienė
1

  1. Translational health research Institute, Faculty of Medicine, Vilnius University, Lithuania
  2. Department of Medical Sciences and Public Health, University of Cagliari, Italy
  3. Department of Life and Environmental Sciences, University of Cagliari, Italy
  4. Graduate School of Health and Sports Science, Juntendo University, Japan
  5. College of Sport and Health Science, Ritsumeikan University, Japan
  6. Faculty of Sport Sciences, Waseda University, Japan
  7. Department of Physical Education, Gdansk University of Physical Education and Sport, Poland
Biol Sport. 2025;42(3):69–77
DOI: https://doi.org/10.5114/biolsport.2025.146786
Online publish date: 2025/01/20
Article file
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1. Ginevičienė V, Utkus A, Pranckevičienė E, Semenova E A, Hall E C R, Ahmetov I I. Perspectives in sports genomics. Biomedicines. 2022; 10(2):1–16.
2. Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001; 24:677–736.
3. Strońska A, Boroń A, Grzywacz A. Consequences of the rs6265 (Val66Met) polymorphism in the BDNF gene in selected mental disorders and sport. Current Problems of Psychiatry. 2022; 23(1):24–33.
4. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003 Aug; 60(8):804–15.
5. Durazzo TC, McNerney MW, Hansen AM, Gu M, Sacchet MD, Padula CB. BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex. Drug Alcohol Depend. 2023 Jul 01; 248:109901.
6. Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. Elife. 2016 Jun 02; 5.
7. Neeper SA, Gómez-Pinilla F, Choi J, Cotman C. Exercise and brain neurotrophins. Nature. 1995 Jan 12; 373(6510):109.
8. Rossi C, Angelucci A, Costantin L, Braschi C, Mazzantini M, Babbini F, et al. Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci. 2006 Oct; 24(7):1850–6.
9. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci. 2004 Nov; 20(10):2580–90.
10. de Assis GG, Hoffman JR, Bojakowski J, Murawska-Ciałowicz E, Cięszczyk P, Gasanov EV. The Val66 and Met66 Alleles-Specific Expression of BDNF in Human Muscle and Their Metabolic Responsivity. Front Mol Neurosci. 2021; 14:638176.
11. Kwon JH, Moon KM, Min KW. Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview. Healthcare (Basel). 2020 Oct 01; 8(4).
12. Voss MW, Erickson KI, Prakash RS, Chaddock L, Kim JS, Alves H, et al. Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behav Immun. 2013 Feb; 28:90–9.
13. Severinsen MCK, Pedersen BK. Muscle-Organ Crosstalk: The Emerging Roles of Myokines. Endocr Rev. 2020 Aug 01; 41(4):594–609.
14. Donati F, Sian V, Biasini GM, de la Torre X, Folchitto F, Botrè F. Serum Levels of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Elite Athletes: Potential Markers of the Use of Transcranial Direct Current Stimulation in Sport. Front Sports Act Living. 2021; 3:619573.
15. Laurens C, Bergouignan A, Moro C. Exercise-Released Myokines in the Control of Energy Metabolism. Front Physiol. 2020; 11:91.
16. Lemos JR, Alves CR, de Souza SB, Marsiglia JD, Silva MS, Pereira AC, et al. Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism. Physiol Genomics. 2016 Feb; 48(2):116–23.
17. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003 Jan 24; 112(2):257–69.
18. Chan CB, Ye K. Sex differences in brain-derived neurotrophic factor signaling and functions. J Neurosci Res. 2017 Jan 02; 95(1–2):328–35.
19. Murtagh CF, Brownlee TE, Rienzi E, Roquero S, Moreno S, Huertas G, et al. The genetic profile of elite youth soccer players and its association with power and speed depends on maturity status. PLoS One. 2020; 15(6):e0234458.
20. Losenkov IS, Mulder NJV, Levchuk LA, Vyalova NM, Loonen AJM, Bosker FJ, et al. Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients. Front Psychiatry. 2020; 11:38.
21. Abbasian S, Yoosefee S, Shahsavand-Ananloo E. Association between brain-derived neurotropic factor gene variant (rs6265; C > T) and schizophrenia, its psychopathology and intelligence. The European Journal of Psychiatry. 2021 2021/10/01/; 35(4):207–15.
22. Raucci FJ, Singh AP, Soslow J, Markham LW, Zhong L, Aljafar W, et al. The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy. Int J Mol Sci. 2020 Oct 10; 21(20).
23. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes. 2010 Dec; 59(12):3085–9.
24. Asai T, Abe D, Doi H, Tanaka C, Ohishi K, Maeda H, et al. Characteristics of the BDNF Val66Met Polymorphism in Competitive Swimmers and Judo Athletes. Acta Medica Nagasakiensia. 2020; 64:23–29.
25. Meyer M, Kircher M, Gansauge MT, Li H, Racimo F, Mallick S, et al. A high coverage genome sequence from an archaic Denisovan individual. Science. 2012 Oct 12; 338(6104):222–6.
26. Mang CS, McEwen LM, MacIsaac JL, Snow NJ, Campbell KL, Kobor MS, et al. Exploring genetic influences underlying acute aerobic exercise effects on motor learning. Sci Rep. 2017 Sep 21; 7(1):12123.
27. Jacob Y, Chivers P, Anderton RS. Genetic predictors of match performance in sub-elite Australian football players: A pilot study. J Exerc Sci Fit. 2019 Jan 20; 17(2):41–6.
28. Urnikyte A, Flores-Bello A, Mondal M, Molyte A, Comas D, Calafell F, et al. Patterns of genetic structure and adaptive positive selection in the Lithuanian population from high-density SNP data. Sci Rep. 2019 Jun; 9(1):9163.
29. Urnikyte A, Pranckeniene L, Domarkiene I, Dauengauer-Kirliene S, Molyte A, Matuleviciene A, et al. Inherited and De Novo Variation in Lithuanian Genomes: Introduction to the Analysis of the Generational Shift. Genes. 2022; 13(4):569.
30. Sheikh HI, Hayden EP, Kryski KR, Smith HJ, Singh SM. Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR. Psychiatr Genet. 2010; 20(3):109–112.
31. Chen S, Francioli LC, Goodrich JK, Collins RL, Kanai M, Wang Q, et al. A genomic mutational constraint map using variation in 76,156 human genomes. Nature. 2024 2024/01/01; 625(7993):92–100.
32. Urnikyte A, Molyte A, Kučinskas V. Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania. Genes (Basel). 2021 Oct 28; 12(11).
33. Bay ML, Pedersen BK. Muscle-Organ Crosstalk: Focus on Immunometabolism. Front Physiol. 2020; 11:567881.
34. Antrobus MR, Brazier J, Callus P, Herbert AJ, Stebbings GK, Day SH, et al. Concussion-Associated Gene Variant COMT rs4680 Is Associated With Elite Rugby Athlete Status. Clin J Sport Med. 2023 Sep 01; 33(5):e145–e51.
35. Guilherme JPLF, Semenova EA, Borisov OV, Kostryukova ES, Vepkhvadze TF, Lysenko EA, et al. The BDNF-increasing allele is associated with increased proportion of fast-twitch muscle fibers, handgrip strength, and power athlete status. J Strength Cond Res. 2022; 36(7):1884–1889.
36. León-Ariza HH, Mendoza-Navarrete MP, Maldonado-Arango MI, Botero-Rosas DA. A systematic review of “myokines and metabolic regulation”. Apunts Sports Medicine. 2018; 53(200):155–62.
37. Fatma R, Chauhan W, Shahi MH, Afzal M. Association of BDNF gene missense polymorphism rs6265 (Val66Met) with three quantitative traits, namely, intelligence quotient, body mass index, and blood pressure: A genetic association analysis from North India. Front Neurol. 2022; 13:1035885.
38. Omura T, Sano M, Omura K, Hasegawa T, Doi M, Sawada T, et al. Different expressions of BDNF, NT3, and NT4 in muscle and nerve after various types of peripheral nerve injuries. J Peripher Nerv Syst. 2005 Sep; 10(3):293–300.
39. Papathanassoglou ED, Miltiadous P, Karanikola MN. May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? Critical Review and Synthesis of Evidence. Biol Res Nurs. 2015 Oct; 17(5):521–39.
40. Nguyen VT, Hill B, Sims N, Heck A, Negron M, Lusk C, et al. Brain-derived neurotrophic factor rs6265 (Val66Met) single nucleotide polymorphism as a master modifier of human pathophysiology. Neural Regen Res. 2023 Jan; 18(1):102–6.
Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
  
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