Breast carcinoma grading on core needle biopsy – to grade or not to grade?

Joanna Szpor; Karolina Witczak; Monika Storman; Anna Streb-Smoleń; Agnieszka Krzemień; Krzysztof Okoń; Diana Hodorowicz-Zaniewska; Joanna Streb

doi:10.5114/pjp.2023.132225

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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3/2023
vol. 74

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abstract:

Original paper

Breast carcinoma grading on core needle biopsy – to grade or not to grade?

Joanna Szpor

¹

,

Karolina Witczak

¹

,

Monika Storman

^{1, 2}

,

Anna Streb-Smoleń

³

,

Agnieszka Krzemień

¹

,

Krzysztof Okoń

¹

,

Diana Hodorowicz-Zaniewska

⁴

,

Joanna Streb

⁵

Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow, Poland
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland
Department of Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland
General, Oncological, and Gastrointestinal Surgery, Jagiellonian University Medical College, Krakow, Poland
Department of Oncology, Jagiellonian University Medical College, Krakow, Poland

Pol J Pathol 2023; 74 (3): 203-210

DOI: https://doi.org/10.5114/pjp.2023.132225

Online publish date: 2023/10/25

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Core needle biopsy (CNB) is well established as an important diagnostic tool in diagnosing breast cancer and it is now considered the initial method of choice for diagnosing breast disease and the basis for the treatment planning. The concordance rate between CNB and surgical excision specimen in determination of histological grade (HG) varies widely across literature, ranging from 59-91%. The aim of our study was to investigate the level of concordance between CNB and surgical excision specimen for the determination of HG for breast cancer patients. The study population included 157 women with a breast tumor who underwent a core needle biopsy for breast carcinoma and a subsequent surgical excision of the tumor. The concordance level between core needle biopsy and surgical resection specimen for overall histologic grading was 73%: for tubule formation – 71%, for nuclear pleomorphism – 91%, for the mitotic index – 59%. Our study shows that our institution’s histologic grading of CNBs and surgical excisions shows a fairly good correlation and is useful for the planning of treatment.

keywords:

Breast carcinoma grading on core needle biopsy – to grade or not to grade?

Joanna Szpor 1 , Karolina Witczak 1 , Monika Storman 1, 2 , Anna Streb-Smoleń 3 , Agnieszka Krzemień 1 , Krzysztof Okoń 1 , Diana Hodorowicz-Zaniewska 4 , Joanna Streb 5

breast cancer, grading, core needle biopsy

Joanna Szpor

¹

,

Karolina Witczak

¹

,

Monika Storman

^{1, 2}

,

Anna Streb-Smoleń

³

,

Agnieszka Krzemień

¹

,

Krzysztof Okoń

¹

,

Diana Hodorowicz-Zaniewska

⁴

,

Joanna Streb

⁵