Structure and functions of ErbB (<i>HER</i>) receptors

Bogdan Falkiewicz; Krzysztof P. Bielawski; Ulf Vogt

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

**Structure and functions of ErbB (HER) receptors**

Bogdan Falkiewicz

,

Krzysztof P. Bielawski

,

Ulf Vogt

Współcz Onkol (1999) 6, 241-243

Online publish date: 2003/08/07

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The paper describes general characteristics, classification and structure of the tyrosine kinase receptor family ErbB (HER). They are encoded by two well-known proto-oncogenes erbB-1 (HER1, egfr) and erbB-2 (HER2, neu), as well as two genes of probably oncogenic function, namely erbB-3 (HER3) and erbB-4 (HER4). Receptors’ ligands, scheme of dimerisation, signal transduction and function were reviewed. Mechanisms leading to excessive activity of the receptor kinases (probably related to their oncogenic potential) were also denoted.

keywords:

Structure and functions of ErbB (HER) receptors

Bogdan Falkiewicz , Krzysztof P. Bielawski , Ulf Vogt

oncogenes, tyrosine kinases, ErbB (HER) receptors

**Structure and functions of ErbB (HER) receptors**

Bogdan Falkiewicz

,

Krzysztof P. Bielawski

,

Ulf Vogt