Butyric acid in functional constipation

Aleksandra Pituch; Jarosław Walkowiak; Aleksandra Banaszkiewicz

doi:10.5114/pg.2013.38731

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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5/2013
vol. 8

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abstract:

Review paper

Butyric acid in functional constipation

Aleksandra Pituch

,

Jarosław Walkowiak

,

Aleksandra Banaszkiewicz

Prz Gastroenterol 2013; 8 (5): 295–298

DOI: https://doi.org/10.5114/pg.2013.38731

Online publish date: 2013/10/28

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Butyric acid, a short-chain fatty acid, is a major energy source for colonocytes. It occurs in small quantities in some foods, and in the human body, it is produced in the large intestine by intestinalkacteria. This production can be reduced in some cases, for which butyric acid supplementation may be useful. So far, the use of butyric acid in the treatment of gastrointestinal disorders has been limited because of its specific characteristics such as its rancid smell and rapid absorption in the upper gastrointestinal tract. In the Polish market, sodium butyrate has been recently made available, produced by the modern technology of microencapsulation, which allows the active substance to reach the small and large intestines, where butyrate easily dissociates into butyric acid. This article presents the potential beneficial mechanisms of action of butyric acid in defecation disorders, which are primarily associated with reductions in pain during defecation and inflammation in the gut, among others.

keywords:

Butyric acid in functional constipation

Aleksandra Pituch , Jarosław Walkowiak , Aleksandra Banaszkiewicz

butyric acid, sodium butyrate, defecation disorders

Aleksandra Pituch

,

Jarosław Walkowiak

,

Aleksandra Banaszkiewicz