Butyric acid in irritable bowel syndrome

Andrzej Załęski; Aleksandra Banaszkiewicz; Jarosław Walkowiak

doi:10.5114/pg.2013.39917

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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6/2013
vol. 8

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abstract:

Review paper

Butyric acid in irritable bowel syndrome

Andrzej Załęski

,

Aleksandra Banaszkiewicz

,

Jarosław Walkowiak

Prz Gastroenterol 2013; 8 (6): 350–353

DOI: https://doi.org/10.5114/pg.2013.39917

Online publish date: 2013/12/30

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Butyric acid (butanoic acid) belongs to a group of short-chain fatty acids and is thought to play several beneficial roles in the gastrointestinal tract. Butyric anion is easily absorbed by enteric cells and used as a main source of energy. Moreover, butyric acid is an important regulator of colonocyte proliferation and apoptosis, gastrointestinal tract motility and bacterial microflora composition in addition to its involvement in many other processes including immunoregulation and anti-inflammatory activity. The pathogenesis of irritable bowel syndrome (IBS), the most commonly diagnosed functional gastrointestinal condition, is complex, and its precise mechanisms are still unclear. This article describes the potential benefits of butyric acid in IBS.

keywords:

Butyric acid in irritable bowel syndrome

Andrzej Załęski , Aleksandra Banaszkiewicz , Jarosław Walkowiak

butyric acid, sodium butyrate, irritable bowel syndrome

Andrzej Załęski

,

Aleksandra Banaszkiewicz

,

Jarosław Walkowiak