C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study

Marek Zawadzki; Roman Czarnecki; Marek Rzaca; Zbigniew Obuszko; Vamsi Ramana Velchuru; Wojciech Witkiewicz

doi:10.5114/wiitm.2015.56999

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2015
vol. 10

Send email

Copy url:

abstract:

Original paper

C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study

Marek Zawadzki

,

Roman Czarnecki

,

Marek Rzaca

,

Zbigniew Obuszko

,

Vamsi Ramana Velchuru

,

Wojciech Witkiewicz

Videosurgery Miniinv 2015; 10 (4): 567–573

DOI: https://doi.org/10.5114/wiitm.2015.56999

Online publish date: 2016/01/12

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Zawadzki M, Czarnecki R, Rzaca M, Obuszko Z, Velchuru V, Witkiewicz W. C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study. Videosurgery and Other Miniinvasive Techniques. 2015:567-573. doi:10.5114/wiitm.2015.56999.

APA

Zawadzki, M., Czarnecki, R., Rzaca, M., Obuszko, Z., Velchuru, V.,  & Witkiewicz, W. (2015). C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study. Videosurgery and Other Miniinvasive Techniques, 567-573. https://doi.org/10.5114/wiitm.2015.56999

Chicago

Zawadzki, Marek, Roman Czarnecki, Marek Rzaca, Zbigniew Obuszko, Vamsi Ramana Velchuru,  and Wojciech Witkiewicz. 2015. "C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study". Videosurgery and Other Miniinvasive Techniques: 567-573. doi:10.5114/wiitm.2015.56999.

Harvard

Zawadzki, M., Czarnecki, R., Rzaca, M., Obuszko, Z., Velchuru, V.,  and Witkiewicz, W. (2015). C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study. Videosurgery and Other Miniinvasive Techniques, pp.567-573. https://doi.org/10.5114/wiitm.2015.56999

MLA

Zawadzki, Marek et al. "C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study." Videosurgery and Other Miniinvasive Techniques, 2015, pp. 567-573. doi:10.5114/wiitm.2015.56999.

Vancouver

Zawadzki M, Czarnecki R, Rzaca M, Obuszko Z, Velchuru V, Witkiewicz W. C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study. Videosurgery and Other Miniinvasive Techniques. 2015:567-573. doi:10.5114/wiitm.2015.56999.

PlumX metrics:

Introduction: Early safe discharge is paramount for the success of ERAS following colorectal cancer resections. Anastomotic leakage (AL) has high morbidity, particularly if the patient has been discharged to the community.

Aim: To evaluate whether C-reactive protein (CRP) and procalcitonin (PCT) can predict AL before early discharge.

Material and methods: Fifty-five consecutive patients undergoing open and robotic colorectal cancer resections were included. C-reactive protein and PCT were measured pre-operatively, 8 h after incision, and on the first and third postoperative day. Thirty-day readmissions, re-operations and mortality were recorded.

Results: Twenty-nine patients underwent robotic and the remainder open (n = 26) resections. Five patients had AL. The mean CRP and PCT increased on postoperative day 1 (POD 1) and POD 3 in all patients. On POD 3, mean CRP was 114 mg/l in non-AL patients and 321 mg/l in AL patients (p = 0.0001). Mean PCT on POD 3 was 0.56 ng/ml in the non-AL group and 10.4 ng/ml in AL patients (p = 0.017). On analysis of ROC and AUC curves, the cut-off for CRP on POD 3 was 245.64 mg/l, with 100% sensitivity and 98% specificity for AL. The cut-off for PCT on POD 3 was 3.83 ng/ml, with 75% sensitivity and 100% specificity for AL.

Conclusions: C-reactive protein and PCT measurement on POD 3 following colorectal cancer resection can positively identify patients at low risk of anastomotic leakage.

keywords:

C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study

Marek Zawadzki , Roman Czarnecki , Marek Rzaca , Zbigniew Obuszko , Vamsi Ramana Velchuru , Wojciech Witkiewicz

colorectal cancer, robotic surgery, anastomosis leak, C-reactive protein, open surgery, colorectal

Marek Zawadzki

,

Roman Czarnecki

,

Marek Rzaca

,

Zbigniew Obuszko

,

Vamsi Ramana Velchuru

,

Wojciech Witkiewicz