CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Plamen Minkov; Maya Gulubova; Koni Ivanova; Evelin Obretenov; Julian Ananiev

doi:10.5114/pjp.2019.87102

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2019
vol. 70

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abstract:

Original paper

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Plamen Minkov

¹

,

Maya Gulubova

¹

,

Koni Ivanova

¹

,

Evelin Obretenov

²

,

Julian Ananiev

¹

Department of General and Clinical Pathology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Department of Thoracic Surgery, Medical Faculty, Trakia University, Stara Zagora, Bulgaria

Pol J Pathol 2019; 70 (2): 109-114

DOI: https://doi.org/10.5114/pjp.2019.87102

Online publish date: 2019/09/03

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Our aim was to analyzed the significance of CD11c and CD123 positive DCs and their relations with some clinical and pathologic parameters of patients with non-small cell lung cancer (NSCLC).

The immunohistochemical expression of CD11c and CD123, was evaluated in 40 patients with NSCLC.

After analysis we found that 35.3% of the patients in the T3-4 tumour stage had a high CD11c infiltration in the tumour stroma, while 100% of the patients in the T1-2 tumour stage had low infiltration (p = 0.03). We also found that 71.4%

of patients in the M1 stage had a high infiltration with CD123 in the tumour stroma, whereas only 15.6% of patients without metastases had high infiltration, analogous data are also found in comparing the distribution of CD123 in the tumour border (p = 0.002 or p = 0.002). Comparing the density of CD123 in the border of lymph node involvement, we found that only 7.14% of patients without metastases had low infiltration with dendritic cells, whereas in patients with metastatic lymph nodes that percentage was 41.7% (p = 0.008).

In conclusion results suggest that CD11c- and CD123-positive DCs play an important role in antitumour immunity and can be predictive factor for tumour development in patients with NSCLC.

keywords:

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Plamen Minkov 1 , Maya Gulubova 1 , Koni Ivanova 1 , Evelin Obretenov 2 , Julian Ananiev 1

NSCLC, dendritic cells, CD11c, CD123

Plamen Minkov

¹

,

Maya Gulubova

¹

,

Koni Ivanova

¹

,

Evelin Obretenov

²

,

Julian Ananiev

¹