CORRELATION ANALYSIS OF BNP CONCENTRATION AND RENAL FUNCTION PARAMETERS IN PATIENTS AFTER PERMANENT PACEMAKER IMPLANTATION

Introduction: The group of patients with implanted cardiac pacemakers is systematically increasing. Changes in the circulatory system after pacemaker implantation are related, amongst others, to the secretion of B-type natriuretic peptide (BNP) to the blood and changes in renal functions.

Material and methods: The study group consisted of 117 patients who underwent permanent implantation of a pacemaker with AAI/R, DDD/R or VVI/R pacing mode. On the day of the implantation, and within three and six months after the performed surgery, BNP, urea and creatinine levels were determined and creatinine clearance was estimated according to the MDRD formula.

Results: Significant correlations between plasma BNP level and the primary renal function parameters were observed before and after permanent pacemaker implantation.

Conclusions: Significant changes in serum creatinine and urea level as well as in eGFR are observed after pacemaker implantation. There are numerous correlations between the secretion of B-type natriuretic peptide into the blood and the primary renal function parameters.