CORRELATION BETWEEN INDICATORS OF HYPOVOLEMIA AND RESPONSE TO INFUSION THERAPY IN FLUID RESUSCITATION OF PATIENTS WITH SEPTIC SHOCK

Introduction
Infusion therapy is the primary stage of resuscitation in patients with septic shock. But excess fluids may cause adverse outcomes, so which indicators should doctors monitor to predict whether the infusion volume is sufficient?

Material and methods
The prospective clinical study included 68 consecutive intensive care unit (ICU) adult patients with septic shock, who had an active surgical infection. Minimally invasive methods were used to continuously record cardiac output (CO). In this study, we compare the passive leg raise (PLR) test and initial central venous oxygen saturation (ScvO2) levels in terms of correlation with, and predictive accuracy for, infusion response.

Results
The predictive accuracy of PLR testing and initial ScvO2 levels for infusion response was 55.9% vs. 67.6% in septic shock patients with abdominal infection. Results from the PLR test and reaction to infusion therapy revealed a slight positive correlation (R=0.239, P=0.018), initial ScvO2 and reaction to infusion therapy revealed a moderate negative correlation (R=-0.305, P=0.009).

Conclusions
In intra-abdominal septic shock patients, the PLR test is not a reliable predictor of response to infusion, but low initial ScvO2 levels can be used for the prediction of response to infusion. Administering a fluid challenge with dynamic indicators (such as CO) is the most accurate method for clinicians to determine the need for further infusion therapy.