Caesarean scar pregnancy: descriptive paper of three different types
of management on a series of clinical cases

Ferdinando Antonio Gulino; Elisa Pappalardo; Carla Ettore; Antonio Simone Laganà; Stella Capriglione; Giuseppe Ettore

doi:10.5114/pm.2020.97836

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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2/2020
vol. 19

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abstract:

Original paper

Caesarean scar pregnancy: descriptive paper of three different types of management on a series of clinical cases

Ferdinando Antonio Gulino

¹

,

Elisa Pappalardo

¹

,

Carla Ettore

¹

,

Antonio Simone Laganà

²

,

Stella Capriglione

³

,

Giuseppe Ettore

¹

Department of Obstetrics and Gynecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi, Catania, Italy
Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy
Department of Obstetrics and Gynaecology, Campus Bio-Medico University, Rome, Italy

Menopause Rev 2020; 19(2): 61-65

DOI: https://doi.org/10.5114/pm.2020.97836

Online publish date: 2020/07/13

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Introduction
A caesarean scar pregnancy is a complex iatrogenic pathology, which represents a consequence of a previous caesarean section. It increased in recent years due to parallel increase of cesarean sections.

Material and methods
We present a retrospective study on patients with caesarean scar pregnancy diagnosed in our department from June 2016 to June 2019. Stable women with an embryo (with or without cardiac activity) who accepted our experimental protocol were treated with single dose of methotrexate (50 mg administered locally intracavitary + 50 mg administered intramuscularly) and folinic acid (15 mg/day orally for 30 days). Clinically stable women with embryo (without cardiac activity) who decided to wait, were monitored by serial assays of b-hCG and clinical and ultrasonographic follow up. Women who were clinically unstable with embryo (without cardiac activity), were referred for urgent surgical treatment with dilation and curettage.

Results
Caesarean scar pregnancy was diagnosed in sixteen women. Among these women, seven were treated according to our experimental protocol with methotrexate and folinic acid and only one had profuse bleeding, which required a laparotomic hysterectomy. Four women were treated urgently with dilatation and curettage. Five women chose to wait: they were monitored and all spontaneously had a miscarriage.

Conclusions
In our preliminary study, we highlighted how our experimental protocol gave encouraging results in the first 10 weeks of caesarean scar pregnancy. However, caution is needed in patients with advanced gestational age, a gestational sac with large diameter, higher CRL and presence of embryonic cardiac activity.

keywords:

Caesarean scar pregnancy: descriptive paper of three different types of management on a series of clinical cases

Ferdinando Antonio Gulino 1 , Elisa Pappalardo 1 , Carla Ettore 1 , Antonio Simone Laganà 2 , Stella Capriglione 3 , Giuseppe Ettore 1

caesarean scar pregnancy, methotrexate, expectant management, dilatation and curettage, miscarriage

Ferdinando Antonio Gulino

¹

,

Elisa Pappalardo

¹

,

Carla Ettore

¹

,

Antonio Simone Laganà

²

,

Stella Capriglione

³

,

Giuseppe Ettore

¹