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ISSN: 1233-9687
Polish Journal of Pathology
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4/2014
vol. 65
 
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Case report
Mercury-induced nephrotic syndrome: a case report and review of the literature

Małgorzata Wągrowska-Danilewicz
,
Marian Danilewicz
,
Zbigniew Zbrog

Pol J Pathol 2014; 65 (4): 322-326
DOI: https://doi.org/10.5114/pjp.2014.48194
Online publish date: 2015/02/02
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A 42-year-old man was admitted to the Nephrology Department because of nephrotic syndrome. Eight months prior to admission he attempted suicide by intravenous self-injection of 2.5 ml of elemental mercury. Renal biopsy was performed. Light microscopy findings showed normal glomeruli and injury of proximal tubular cells. Immunofluorescence was negative, and electron microscopy study revealed diffuse effacement of podocyte foot processes and vacuolization of podocyte cytoplasm. Minimal change disease was diagnosed. The patient was treated with 2,3-dimercaptopropane-1-sulfonate, for mercury detoxification, and steroids. In one-year follow-up the 24-h urine protein excretion decreased from 30 γ to 0.186 g, and the renal function remain normal. The presented case indicates that mercury intoxication should be mentioned as a cause of secondary minimal change disease.
keywords:

mercury intoxication, nephrotic syndrome, minimal change disease
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