Case report
Omalizumab treatment in brittle asthma

Introduction

Omalizumab is a humanized monoclonal anti-IgE antibody developed for the treatment of IgE-mediated diseases, including asthma. So far the influenc2 omalizumab treatment on brittle asthma is not known.

Case reports

Case 1



We describe a 46-year-old female with 30 years’ history of type 1 brittle asthma. Despite continuous therapy with a combination of 2 agonist, high doses of inhaled corticosteroids (ciclesonide 640 mg twice daily), and montelukast, her asthma was not well controlled. The patient suffered from death-threatening asthma exacerbations 4–5 times per year. These events usually began with fast progressive paroxysmal dyspnea with a low effect of short acting 2 agonist (SABA), wheezes in the chest and severe decrease in peak expiratory flow (PEF). For a few hours the patient had progressive dyspnea, tachycardia, disturbances of consciousness and finally she lost her consciousness. Typically, the emergency rescue (ER) team in physical examination found: Glascow Coma Scale (GCS) 6 pct, cyanosis, fast shallow respiration 30/min, silent vesicular murmur, heart rate (HR) 140/min, blood pressure 70/50 mm Hg. After treatment according to GINA guidelines, the patient regained consciousness after several minutes and returned to stable condition after 3–6 days of hospitalization. The patient underwent neurological and cardiological examination to diagnose the cause of faint. No other cause, except severe asthma exacerbation has been found.

In stable condition her pulmonary function test showed: forced expiratory volume in 1 s/forced vital capacity (VEV1/FVC) ratio of 54.12%; FEV1 – 1.31 l, 55.7% of predicted value, FVC – 2.17 l, 78.5% of predicted value, daily variation of PEF > 40%, and exhaled nitric oxide (FeNO) concentration of 24 ppb. A Skin Prick Test (SPT) with common allergens was positive for dust mites. The patient had IgE level of 66 IU/ml, sIgE to Dermatophagoides pteronyssinus: 26 IU/ml, class 4. The patient did not achieve asthma symptom control despite adhering to current guidelines-based standards of therapy and had been qualified to omalizumab therapy.

According to the manufacturer’s recommendations, the treatment consisted of 150 mg of omalizumab in subcutaneous injections given every 4 weeks.

After a few months, the patient achieved a significant improvement in asthma control test score and symptoms, reduction in rescue medication use, significant decrease in acute asthma episodes and hospitalizations. In the following 60 months of omalizumab treatment, the patient did not experience severe exacerbations accompanied with loss of consciousness. There were no emergency or hospital admissions for asthma and only 3 courses of systemic steroids during 5 years were administered during asthma exacerbations over that period.



Case 2



We report the case of a 26-year-old female, with 10 years’ history of asthma. She was treated with inhaled corticosteroids (fluticasone 2000 g/day), 2 agonist, and montelukast 10 mg/day. Despite treatment with a high dose of inhaled corticosteroids (ICS) and montelukast, she suffered from frequent, sudden asthma attacks (2–3/month) with a decrease of PEF > 40%. These episodes required treatment with high doses of SABA and sometimes systemic corticosteroids. After several hours, symptoms used to disappear and PEF increased. We diagnosed brittle asthma type 2.

In stable condition her pulmonary function test showed: FEV1/FVC ratio of 101.8%; FEV1 – 3.91 l, 100.5% of predicted value, FVC – 4.51 l, 101.8% of predicted value, PEF 650 l/min, FeNO concentration of 120 ppb. A SPT with common allergens was positive for dust mites. The patient had IgE level of 460 IU/ml, sIgE to D. pteronyssinus: > 100 IU/ml, class 6.

To improve asthma control, omalizumab treatment was added to the maintenance therapy. According to the manufacturer’s recommendations, 300 mg of omalizumab was administered every 2 weeks.

After 16 weeks of treatment, the patient achieved a significant improvement in asthma control. Over the next

16 months of treatment with omalizumab, she did not suffer from asthma exacerbation episodes with a PEF decrease > 40% and administration of systemic corticosteroids.

Discussion

Asthma is a heterogeneous disease with variable characteristics such as lung function, symptoms and control, body weight, pattern of inflammation, and response to treatment. Brittle asthma is one of clinical phenotypes of asthma. Two types of brittle asthma can be identified. Type I brittle asthma is characterized by more than 40% of diurnal variation in PEF for more than 50% of time maintained over a period of at least 150 days despite considerable medical therapy. Type II brittle asthma is characterized by sudden acute attacks occurring in less than 3 h on the background of apparent normal airway function or well-controlled asthma [1].

The possible mechanism of omalizumab efficacy in brittle asthma is unknown, probably because risk factors of developing this clinical asthma phenotype are unclear. In type I of brittle asthma, several factors including atopy, relative immunoglobulin deficiency, impaired hypoxic driver or ventilatory response, nutrient deficiency, psychological factors, food intolerance, autonomic imbalance, relative resistance to the anti-inflammatory action may be important [2, 3]. For patients with the disease of type 2 there are no published data on risk factors.

More than 90% of brittle asthma patients are atopic [4]. Omalizumab prevents binding of IgE to high-affinity (FcRI) or low affinity (FcRII) receptors on several inflammatory cell types. It inhibits initiation of inflammatory cascade after exposure to an allergen, thus prohibiting induction of cell activation and release of inflammatory mediators, which contribute to acute and chronic symptoms of asthma [5, 6]. Treatment with anti-IgE significantly reduces the airway eosinophilia in the induced sputum, epithelium and submucosal layers, decreases levels of circulating cytokines IL-13, IL-5, serum eosinophil cationic protein (ECP) and eotaxin, decreases the concentrations of RANTES and endothelin-1 (ET-1) in exhaled breath condensate, and decreases concentration of FeNo [7–9].

The prevalence of brittle asthma is not well known. Data from the West Midlands Brittle Asthma Register in the UK suggest that it occurs in 0.05% of all asthmatics. Although the brittle asthma is a rare clinical phenotype of the disease, it is an important medical and socioeconomic issue. Patients with brittle asthma require frequent hospital admissions, emergency attendances and ventilation in acute attacks. Both groups have an increased risk of death from asthma during episodes of acute asthma attacks [10]. Morbidity is also increased by therapy side-effects, notably from oral corticosteroids and 2 agonists.

To our knowledge, it is the first publication on efficacy of omalizumab in patients with brittle asthma. Analysis of the described cases suggests that omalizumab, despite so far unclear pathogenic mechanisms, could be useful in the treatment of brittle allergic asthma.

Acknowledgments

The data were presented as a poster at EAACI-WAO Congress, 22-26 June 2013, Milan, Italy

References

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