Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
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3/2017
vol. 34
 
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abstract:
Original paper

Cell free DNA as a marker of training status in weightlifters

Jeremy A. Gentles
1
,
William G. Hornsby
2
,
Christine L. Coniglio
1
,
Andrew R. Dotterweich
3
,
Jon A. Miller
3
,
Charles A. Stuart
4
,
Michael H. Stone
3

  1. Armstrong State University, Department of Health Sciences, Savannah, Georgia
  2. West Virginia University, Department of Coaching and Teaching Studies, Morgantown, West Virginia
  3. East Tennessee State University, Department of Exercise and Sport Science, Johnson City, Tennessee
  4. East Tennessee State University, Department of Internal Medicine, Quillen College of Medicine, Johnson City, Tennessee
Biol Sport 2017;34:287-294
DOI: https://doi.org/10.5114/biolsport.2017.67855
Online publish date: 2017/10/23
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The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities. The relationship between cell free DNA (cf-DNA), C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testosterone-cortisol ratio (T:C), body mass and body composition were also examined. Eight weightlifters (5 males and 3 females, age = 25 ± 3.5 yr, body mass = 88.3 ± 22.7 kg, height = 173.8 ±8.4 cm) volunteered to participate in this study. Venous blood samples, body mass and body composition were taken six times, each corresponding to the end of a training phase. CK (p = 0.018, η² = 0.409) and CK %Δ (p < 0.001, η² = 0.594) were the only biochemical variables to reach statistical significance at any point. A number of statistically significant correlations were found among variables. VLD4wk was related to CK %Δ (r = 0.86), VLD4wk %Δ was related CK %Δ (r = 0.86) and TID1wk was related to CRP (r = 0.83). cf-DNA %Δ was correlated with CRP and CRP %Δ (r = 0.83 and 0.86, respectively). CRP and CRP %Δ were correlated with BF % (r = 0.94 and 0.92, respectively). CK and CK %Δ were both related to T:C (r = 0.94 and 0.89, respectively) and T:C %Δ (r = 0.87 and 0.86, respectively). The correlation between cf-DNA and CRP suggests that cf-DNA may be a valuable indicator of inflammation in weightlifters.
keywords:

Cell free DNA, Inflammation, Resistance training, Athlete monitoring

  
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