eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2019
vol. 44
 
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abstract:
Clinical immunology

Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight

Małgorzata Rumińska
1
,
Ewelina Witkowska-Sędek
1
,
Dorota Artemniak-Wojtowicz
1
,
Maria Krajewska
1
,
Anna Majcher
1
,
Maria Sobol
2
,
Beata Pyrżak
1

  1. Department of Paediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland
  2. Department of Biophysics and Human Physiology, Medical University of Warsaw, Warsaw, Poland
(Centr Eur J Immunol 2019; 44 (3): 307-315)
DOI: https://doi.org/10.5114/ceji.2019.89608
Online publish date: 2019/09/30
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Aim of the study
To assess the changes in the leukocyte profile and C-reactive protein (CRP) concentration in adolescents with excess fat mass after 6-12 months of dietary intervention.

Material and methods
The retrospective study included 99 overweight and obese adolescents, aged from 10.0 to 17.5 years, 82 of whom were re-hospitalized 6 to 12 months after dietary counseling. The control group consisted of 42 normal weight peers. Anthropometric measurements and laboratory tests were performed, homeostasis model assessment – insulin resistance (HOMA-IR) and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio were calculated.

Results
Obese and overweight adolescents had higher white blood cells (WBC), neutrophil, monocyte counts and CRP concentration. In the backward stepwise regression analysis, body mass index standard deviation score (BMI SDS) and fasting insulin concentration were independent predictors of WBC and neutrophil counts at the baseline. At the follow-up visit in 45 (54.8%) children, who had lost weight, decreases in WBC, neutrophil and monocyte counts and CRP, fasting insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) concentrations were observed. Changes in WBC and neutrophil counts were dependent on changes in HOMA-IR and TG/HDL ratio. Changes in HOMA-IR had a significant impact on changes in the monocyte count.

Conclusions
Adipose tissue promotes systemic inflammation and its intensity depends on the degree of obesity and insulin resistance. This state is reversible. Changes in HOMA-IR were independent predictors of changes in WBC, neutrophil and monocyte counts after reduction of body weight.

keywords:

insulin resistance, adolescents, low-grade inflammatory state, leukocyte profile
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