eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
5/1999
vol. 3
 
Share:
Share:
abstract:

Ovarian cancer primary systemic chemotherapy with cyclophosphamide, epirubicin, carboplatin with concomitant intraperitoneal carboplatin

Adam Kaliński
,
Andrzej Staszewski
,
Cezary Szczylik
,
Gabriel Wcisło
,
Jan Korniluk
,
Joanna Sielużycka
,
Paweł Nurzyński
,
Piotr Kowalski
,
Przemysław Langiewicz

Współcz Onkol (1999) 3 (5), 203-207
Online publish date: 2003/08/06
View full text Get citation
 
Purpose. Debulking surgery followed by chemotherapy is a standard in ovarian cancer therapy. The aim of our study was estimation of efficacy of the ovarian cancer primary systemic chemotherapy combinig intravenous carboplatin (CBDCA), cyclophosphamide (CTX), epirubicin (EPI) with concomitant intraperitoneal carboplatin.

Methods. We have enrolled women with ovarian cancer (FIGO II-IV), 70-90% Karnofsky’s score. Median age was 56 years (range, 38-77 years). They received a modified regimen consisting of: CTX – 600 mg/m2 i.v., EPI – 50 mg/m2, CBDCA – 400 mg/m2 plus intraperitoneal CBDCA – 30-40% intravenous dose. Median dose of CTX was 877 mg, CBDCA – 603 mg, EPI – 70 mg, intraperitoneal CBDCA – 167 mg. After the surgery all patients received 205 cycles of chemotherapy (median, 6 [range 3-9 cycles] per patient). All investigated women have been assessed with imaging techniques, hematological & biochemical parameters and serum marker – Ca-125 concentration. Toxicity was assessed using the WHO score schedule. Moreover, laparoscopic evaluation of peritoneal cavity was performed when 3 and 6 chemotherapy cycles were completed.

Results. In the group of 29 patients we observed: 48% (14) CR, 45% (12) PR and 7% (2) SD. Overall response rate of 93% (27 females) was observed. Among 5 patients with FIGO II – 4 CR and 1 PR, FIGO III-7 CR, 12 PR, 2 SD; FIGO IV-1 CR, 2 PR have been observed. Stabilization was noticed in 2 women after debulking surgery. Median duration of response was 11,9 months (range 1-46+ months). Among the total estimated number of 131 cycles of chemotherapy in 35 cases (27%) haematologic toxicities (4th WHO degree) have been observed. During thirty cycles G-CSF/GM-CSF support was required. In one case chemotherapy has been stopped because of severe toxicities.

Conclusion. These results indicate importance of systemic chemotherapy combined with intraperitoneal chemotherapy in patients with ovarian cancer.
keywords:

ovarian cancer, chemotherapy, intraperitoneal chemotherapy, toxicities

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.