eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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1/2019
vol. 5
 
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abstract:
Original paper

Chronic hepatitis B virus infection is associated with decreased serum 25(OH)D concentration in non-cirrhotic patients

Anna Parfieniuk-Kowerda
1
,
Magdalena Świderska
1
,
Magdalena Rogalska
1
,
Magdalena Maciaszek
1
,
Jerzy Jaroszewicz
1, 2
,
Robert Flisiak
1

  1. Medical University of Bialystok, Poland
  2. Medical University of Silesia, Katowice, Poland
Clin Exp HEPATOL 2019; 5, 1: 75–80
DOI: https://doi.org/10.5114/ceh.2019.83160
Online publish date: 2019/03/01
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Aim of the study
Recent reports provide evidence for the immunomodulatory properties of vitamin D. Decreased vitamin D levels may contribute to the progression of liver disease in hepatitis B virus (HBV) infection. This study aims to assess serum 25(OH)D in patients with chronic HBeAg-negative HBV (CHB) infection at different phases of disease.

Material and methods
Fifty-eighty patients with CHB, 10 with a history of HBsAg/anti-HBs seroconversion, were enrolled. The control group consisted of 9 healthy volunteers. Serum 25(OH)D concentration was assessed by ELISA.

Results
25(OH)D concentration was significantly lower in the CHB group in comparison to the HC group. It did not differ across the consecutive phases of the HBeAg-negative HBV infection. Negative correlations between serum 25(OH)D and alanine aminotransferase (ALT) as well as frequency of peripheral blood monocytes were observed. Serum 25(OH)D in samples collected in winter was significantly lower in comparison to the pool of samples collected in the summer. Serum 25(OH)D concentration was not associated with the phases of HBV-infection, HBV viral load, APRI or liver histology.

Conclusions
Serum 25(OH)D is significantly decreased in HBV infection irrespectively of the phase of the infection and negatively correlates with serum ALT level, which may reflect the deterioration of liver function. Based on our results, we can conclude that the role of vitamin D in the immune control of HBV infection is probably irrelevant.

keywords:

HBV, chronic hepatitis B, 25(OH)D
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