eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2024
vol. 75
 
Share:
Send email
Share:
abstract:
Original paper

Classical autoimmune hepatitis and the IgG4-associated autoimmune hepatitis in paediatric patients

Dominika Kaps-Kopiec
1
,
Małgorzata Woźniak
1
,
Dorota Jarzębicka
1
,
Renata Grzywa-Czuba
2
,
Joanna Pawłowska
1
,
Piotr Czubkowski
1
,
Joanna Cielecka-Kuszyk
3

  1. Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children’s Memorial Health Institute, Warsaw, Poland
  2. Department of Microbiology and Clinical Immunology, The Children’s Memorial Health Institute, Warsaw, Poland
  3. Department of Pathology, The Children’s Memorial Health Institute, Warsaw, Poland
Pol J Pathol 2024; 75 (2): 153-156
DOI: https://doi.org/10.5114/pjp.2024.141231
Online publish date: 2024/07/08
View full text Get citation
 
PlumX metrics:
The IgG4-associated autoimmune hepatitis (IgG4-AIH) is a newly proposed disease entity characterised by the accumulation of the IgG4-expressing plasma cells in the liver. Its pathophysiology and clinical significance remain unclear and have poor evidence in the paediatric population. Thus, our study aims at comparing the group of paediatric patients with classical AIH and the IgG4-AIH.

We carried out a retrospective analysis of 23 children (median age 8.5 years) diagnosed with AIH, who were compared according to the presence of IgG4-positive plasma cells in the liver biopsy.

IgG4-AIH was defined if 10 or more IgG4 positive plasma cells/high-power field were found in the biopsy.

The presence of the IgG4 component seems to be clinically insignificant. That is why, the conventional immunosuppressive protocol should be considered the standard treatment in the case of the IgG4-associated AIH.
keywords:

autoimmune hepatitis, immunoglobulin G4-related diseases, children
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.