eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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1/2022
vol. 73
 
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abstract:
Original paper

Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma

Ylermi Soini
1
,
Risto Pirinen
2
,
Kumi Takasawa
3
,
Makoto Osanai
3
,
Akira Takasawa
3

  1. Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, Kuopio, Finland
  2. Department of Pathology, North Karelia Central Hospital, Joensuu, Finland
  3. Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
Pol J Pathol 2022; 74 (1): 1-5
DOI: https://doi.org/10.5114/pjp.2022.117171
Online publish date: 2022/06/28
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We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry.

Samples of 164 patients with NSCLC were studied by immunohistochemistry.

Claudin 6 was expressed in 42 % of cases. Its expression was significantly more frequent in adeno- than in squamous cell carcinoma (p = 0.002). There was no association between the TNM status and claudin 6 expression. Claudin 6 associated with a poor prognosis of the patients and with a short recurrence-free interval (p = 0.002, p < 0.001). The association with survival had independent prognostic value (p = 0.011).

The results show that claudin 6 can be regarded as a marker of poor prognosis in lung cancer. This is different to some other cancers, such as breast and cervical carcinoma suggesting that claudin 6 probably induces other cellular pathways in neoplastic lung cells than in those tumors. In lung cancer, adenocarcinomas were most abundantly positive indicating a higher linkage of claudin 6 to glandular differentiation.
keywords:

claudin, lung, carcinoma, survival, immunohistochemistry
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