Clinical factors predicting blood pressure reduction after catheter-based renal denervation

Krzysztof Bartus; Radosław Litwinowicz; Jerzy Sadowski; Wojciech Zajdel; Maciej Brzeziński; Magdalena Bartus; Paweł Kleczyński; Stanislaw Bartus; Dhanunjaya Lakkireddy; Bogusław Kapelak

doi:10.5114/aic.2018.78330

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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Original paper

Clinical factors predicting blood pressure reduction after catheter-based renal denervation

Krzysztof Bartus

,

Radosław Litwinowicz

,

Jerzy Sadowski

,

Wojciech Zajdel

,

Maciej Brzeziński

,

Magdalena Bartus

,

Paweł Kleczyński

,

Stanislaw Bartus

,

Dhanunjaya Lakkireddy

,

Bogusław Kapelak

Adv Interv Cardiol 2018; 14, 3 (53): 270–275

DOI: https://doi.org/10.5114/aic.2018.78330

Online publish date: 2018/09/21

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AMA

Bartus K, Litwinowicz R, Sadowski J, et al. Clinical factors predicting blood pressure reduction after catheter-based renal denervation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(3):270-275. doi:10.5114/aic.2018.78330.

APA

Bartus, K., Litwinowicz, R., Sadowski, J., Zajdel, W., Brzeziński, M.,  & Bartus, M. et al. (2018). Clinical factors predicting blood pressure reduction after catheter-based renal denervation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(3), 270-275. https://doi.org/10.5114/aic.2018.78330

Chicago

Bartus, Krzysztof, Radosław Litwinowicz, Jerzy Sadowski, Wojciech Zajdel, Maciej Brzeziński, Magdalena Bartus,  and Paweł Kleczyński et al. 2018. "Clinical factors predicting blood pressure reduction after catheter-based renal denervation". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 14 (3): 270-275. doi:10.5114/aic.2018.78330.

Harvard

Bartus, K., Litwinowicz, R., Sadowski, J., Zajdel, W., Brzeziński, M., Bartus, M., Kleczyński, P., Bartus, S., Lakkireddy, D.,  and Kapelak, B. (2018). Clinical factors predicting blood pressure reduction after catheter-based renal denervation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 14(3), pp.270-275. https://doi.org/10.5114/aic.2018.78330

MLA

Bartus, Krzysztof et al. "Clinical factors predicting blood pressure reduction after catheter-based renal denervation." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 14, no. 3, 2018, pp. 270-275. doi:10.5114/aic.2018.78330.

Vancouver

Bartus K, Litwinowicz R, Sadowski J, Zajdel W, Brzeziński M, Bartus M et al. Clinical factors predicting blood pressure reduction after catheter-based renal denervation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2018;14(3):270-275. doi:10.5114/aic.2018.78330.

Introduction
Renal denervation (RD) can lead to a significant and sustained decrease in mean values of arterial blood pressure (BP). However, there is still a subset of patients without a significant BP drop after RD (non-responders).

Aim
To compare characteristics of RD responders to RD non-responders and to identify the clinical predictors of BP reduction.

Material and methods
Thirty-one patients with diagnosed resistant hypertension underwent RD. Three years after RD the analysis of BP reduction was performed in regard to the baseline patient characteristics.

Results
After 3 years’ follow-up a 10% or more reduction of systolic baseline BP was observed in 74% of patients. Ten percent or more reduction of diastolic baseline BP was observed in 71% of patients. Among responders we observed the following risk factors: hypercholesterolemia in 70%, body mass index (BMI) > 30 kg/m2 in 55%, diabetes mellitus in 35%, current smoking in 5%. Comorbidity included coronary artery disease (CAD) in 30%, cardiomyopathy in 10%, chronic obstructive pulmonary disease (COPD) in 10%, renal insufficiency in 10%, and ventricular arrhythmia in 5%. Among non-responders we observed the following risk factors: hypercholesterolemia in 38%, diabetes mellitus type 2 in 38% and BMI > 30 kg/m2 in 86%. Comorbidity included CAD in 50% and cardiomyopathy in 13% of patients.

Conclusions
A 10% reduction of systolic baseline BP was observed in 74% of patients 3 years after renal denervation. Clinical factors like COPD, chronic kidney disease 3a, female sex and hypercholesterolemia increase the chances of effective reduction of BP.

keywords:

Clinical factors predicting blood pressure reduction after catheter-based renal denervation

Krzysztof Bartus , Radosław Litwinowicz , Jerzy Sadowski , Wojciech Zajdel , Maciej Brzeziński , Magdalena Bartus , Paweł Kleczyński , Stanislaw Bartus , Dhanunjaya Lakkireddy , Bogusław Kapelak

hypertension, resistant hypertension, renal denervation

Krzysztof Bartus

,

Radosław Litwinowicz

,

Jerzy Sadowski

,

Wojciech Zajdel

,

Maciej Brzeziński

,

Magdalena Bartus

,

Paweł Kleczyński

,

Stanislaw Bartus

,

Dhanunjaya Lakkireddy

,

Bogusław Kapelak