Clinical immunology
318 C/T polymorphism of cytotoxic T lymphocyte antigen-4 in allegic asthma: functional analysis by gene ontology

Cytotoxic T lymphocyte antigen-4 (CTLA-4) represents one of the most extensively studied receptors in the costimulatory pathway and has recently been shown to function as a potent inhibitor of T cell-mediated immunity. The association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study. However, the role of the CTLA-4 318 C/T change needs a systematic theoretical explanation. However, studies on an association between this polymorphism and clinical findings have yielded some inconsistent findings. To study the functional aberration in the human wild and mutate types of CTLA-4 in pathogenesis is hard. Here, the author used a new gene ontology technology to predict the molecular function of human wild and mutate types of CTLA-4. Here, it can be seen that there is no functional difference between wild and mutate types of CTLA-4. This can support the null effect of this polymorphism in clinical findings of the patients. This polymorphism might not be an important factor and have null effect on cardiovascular disease.