eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2014
vol. 39
 
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abstract:

Clinical immunology
Bouquet variety of antiphospholipid antibodies in recurrent pregnancy loss

Marta P. Baleva
,
Zhivka P. Karagyozova
,
Milena K. Nikolova-Vlahova
,
Krasimir V. Nikolov
,
Petar K. Nikolov

(Centr Eur J Immunol 2014; 39 (3): 352-356)
DOI: https://doi.org/10.5114/ceji.2014.45947
Online publish date: 2014/10/14
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Seventy-six female patients with two or more recurrent pregnancy losses (RPL) during the 1st trimester were studied. Based on the results of the aCL and aB2GPI antibodies testing, patients were divided in two groups: 22 patients with RPL and elevated immunoglobulin (Ig) G/IgM aCL and/or aB2GPI [RPL + antiphospholipid syndrome (APS)] and 54 patients with RPL alone (without high antibodies). Immunoglobulin G aPS and IgG a-AnV in patients with RPL + APS were higher than in controls and IgG aPS were higher in RPL + APS than in RPL alone. Additionally IgG a-AnV and IgM aPE are higher in RPL alone than in controls. In 18/22 (81%) patients with RPL + APS and 29/54 (54%) patients with RPL alone, there were one or more positive antibodies: aPS, aPT, a-AnV or aPE. These results raise a question whether or not these antiphospholipid antibodies should be routinely tested in women with RPL and especially in the context of the so-called “seronegative APS”.
keywords:

antiphospholipid syndrome, antiphospholipid antibodies, recurrent pregnancy loss
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