Clinical immunology<br>Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Helena Rotsztejn; Dorota Chomiczewska; Ewa Trznadel-Grodzka; Dorota Jesionek-Kupnicka

doi:10.5114/ceji.2012.30803

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2012
vol. 37

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abstract:

Clinical immunology
Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Helena Rotsztejn

,

Dorota Chomiczewska

,

Ewa Trznadel-Grodzka

,

Dorota Jesionek-Kupnicka

(Centr Eur J Immunol 2012; 37 (3): 258-263)

DOI: https://doi.org/10.5114/ceji.2012.30803

Online publish date: 2012/10/27

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Introduction: Langerhans cells (LCs) constitute a key component of the skin immune system (SIS). They play some role in the pathogenesis of chronic inflammatory diseases of the skin, including psoriasis. However, their role in psoriasis has not been completely elucidated. The aim of this study was to evaluate LCs density in skin lesions of patients with chronic plaque psoriasis, before and after phototherapy.

Material and methods: 25 patients with plaque psoriasis were included in the study. Biopsies were taken from the skin of their lumbosacral or gluteal area. Then the participants received broadband UVB, narrowband UVB or PUVA therapy. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded skin samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra).

Results: The number of LCs in the study group was lower in lesional skin compared to perilesional skin. After phototherapy we observed an increase in the number of LCs in lesional skin while a decrease of the LCs number was noted in perilesional skin after PUVA treatment.

Conclusions: Psoriatic epidermis is characterized by disturbances in the number of LCs. Our study showed a low number of LCs in chronic psoriatic plaques. At the same time, a high number of LCs in perilesional skin may predict centrifugal enlargement of psoriatic plaques. However, a smaller number of LCs may be observed in chronic lesions. The most considerable increase of LCs number was observed in psoriatic skin of our patients after BB-UVB and PUVA treatment, a slight increase – after NB-UVB therapy.

keywords:

Clinical immunologyDensity of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Helena Rotsztejn , Dorota Chomiczewska , Ewa Trznadel-Grodzka , Dorota Jesionek-Kupnicka

Langerhans cells, psoriasis, phototherapy, CD1a

Clinical immunology
Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Helena Rotsztejn

,

Dorota Chomiczewska

,

Ewa Trznadel-Grodzka

,

Dorota Jesionek-Kupnicka