eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2012
vol. 37
 
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abstract:

Clinical immunology
Interleukin 1β in morphea

Aleksandra Dańczak-Pazdrowska
,
Michał Jacek Kowalczyk
,
Beata Szramka-Pawlak
,
Justyna Gornowicz-Porowska
,
Aleksandra Szewczyk
,
Wojciech Silny
,
Anna Olewicz-Gawlik
,
Marta Molińska-Glura
,
Ryszard Żaba
,
Paweł Hrycaj

(Centr Eur J Immunol 2012; 37 (3): 247-252)
DOI: https://doi.org/10.5114/ceji.2012.30800
Online publish date: 2012/10/27
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Morphea (circumscribed scleroderma, localized scleroderma) represents a disease included into the sceroderma group of autoimmune connective tissue diseases. Interleukin (IL) – 1β may play role in pathogenesis of the disease as a cytokine of pronounced pro-inflammatory properties. The study aimed at evaluation of IL-1β levels in morphea. The study was conducted on 41 blood and 29 skin samples from patients with morphea. The evaluation included: 1) expression of IL-1β gene in peripheral blood mononuclear cells (PBMC) using real-time PCR, 2) plasma levels of IL-1β using ELISA, 3) expression of IL-1β gene in skin by real-time PCR. A significantly higher expression of IL-1β in PBMC of morphea patients and higher plasma levels of the cytokine were disclosed, as compared to healthy controls. No difference was noted in expression of IL-1β in the skin between morphea patients and healthy controls.
keywords:

morphea, scleroderma, interleukin 1β, autoimmune diseases, IL-1
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