Clinical immunology<br> PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections

Adriana Roży; Leszek Jung; Joanna Chorostowska-Wynimko; Ewa Skopińska-Różewska; Ewa Sommer; Adamina Borowska; Bożena Wojciechowska; Adam Szpechciński; Barbara J. Bałan

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ISSN: 1426-3912

Central European Journal of Immunology

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4/2008
vol. 33

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abstract:

Clinical immunology
PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections

Adriana Roży

,

Leszek Jung

,

Joanna Chorostowska-Wynimko

,

Ewa Skopińska-Różewska

,

Ewa Sommer

,

Adamina Borowska

,

Bożena Wojciechowska

,

Adam Szpechciński

,

Barbara J. Bałan

Centr Eur J Immunol 2008; 33 (4): 224-227

Online publish date: 2008/12/24

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AMA

Roży A, Jung L, Chorostowska-Wynimko J, et al. Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections. Central European Journal of Immunology. 2008;33(4).

APA

Roży, A., Jung, L., Chorostowska-Wynimko, J., Skopińska-Różewska, E., Sommer, E.,  & Borowska, A. et al. (2008). Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections. Central European Journal of Immunology, 33(4).

Chicago

Roży, Adriana, Leszek Jung, Joanna Chorostowska-Wynimko, Ewa Skopińska-Różewska, Ewa Sommer, Adamina Borowska,  and Bożena Wojciechowska et al. 2008. "Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections". Central European Journal of Immunology 33 (4).

Harvard

Roży, A., Jung, L., Chorostowska-Wynimko, J., Skopińska-Różewska, E., Sommer, E., Borowska, A., Wojciechowska, B., Szpechciński, A.,  and Bałan, B. (2008). Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections. Central European Journal of Immunology, 33(4).

MLA

Roży, Adriana et al. "Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections." Central European Journal of Immunology, vol. 33, no. 4, 2008.

Vancouver

Roży A, Jung L, Chorostowska-Wynimko J, Skopińska-Różewska E, Sommer E, Borowska A et al. Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections. Central European Journal of Immunology. 2008;33(4).

We previously reported that single enoxaparine dose administered prior to the hip surgery resulted in an increase of angiogenic activity and basic fibroblast growth factor (bFGF) level in patients’ sera without any corresponding alterations in the vascular endothelial growth factor (VEGF) concentration. Increased VEGF serum level, however, was observed in sera after 14 enoxaparine injections. Plasminogen activator inhibitor-1 (PAI-1) levels increased after single enoxaparine dose, and no significant alterations in plasma VEGF, fibrinogen and antithrombin III (AT-III) levels were seen. In the present paper we have study the same parameters in plasma of patients treated with enoxaparine for 2 weeks after surgery.
Significant increase of plasma PAI-1 and fibrinogen concentration, as well as angiogenic plasma activity in vivo in PIA mice cutaneous test, were observed. No alterations in plasma VEGF and AT-III were seen.

keywords:

Clinical immunology PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections

Adriana Roży , Leszek Jung , Joanna Chorostowska-Wynimko , Ewa Skopińska-Różewska , Ewa Sommer , Adamina Borowska , Bożena Wojciechowska , Adam Szpechciński , Barbara J. Bałan

plasma, enoxaparine, angiogenesis, VEGF, PAI-1, fibrinogen, AT-III

Clinical immunology
PAI-1, fibrinogen, AT-III and angiogenic activity of plasma in patients before and 14 days after orthopaedic surgery and 14 daily enoxaparine injections

Adriana Roży

,

Leszek Jung

,

Joanna Chorostowska-Wynimko

,

Ewa Skopińska-Różewska

,

Ewa Sommer

,

Adamina Borowska

,

Bożena Wojciechowska

,

Adam Szpechciński

,

Barbara J. Bałan