Clinical immunology<br>Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan; Tudor Drugan; Nicolae Costin; Razvan Ciortea; Carmen Bucuri; Maria P. Rada; Dan Mihu

doi:10.5114/ceji.2015.50840

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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vol. 40

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abstract:

Clinical immunology
Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan

,

Tudor Drugan

,

Nicolae Costin

,

Razvan Ciortea

,

Carmen Bucuri

,

Maria P. Rada

,

Dan Mihu

(Centr Eur J Immunol 2015; 40 (1): 96-102)

DOI: https://doi.org/10.5114/ceji.2015.50840

Online publish date: 2015/04/22

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The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis.

Material and methods: The study included 160 women, who were divided in two study groups (Group I – endometriosis; Group 2 – healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α (TNF-α) with the use of Human Multiplex Cytokine Panels.

Results: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.

Conclusions: Women with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.

keywords:

Clinical immunologyPro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan , Tudor Drugan , Nicolae Costin , Razvan Ciortea , Carmen Bucuri , Maria P. Rada , Dan Mihu

inflammation, endometriosis, cytokine, interleukin

Clinical immunology
Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan

,

Tudor Drugan

,

Nicolae Costin

,

Razvan Ciortea

,

Carmen Bucuri

,

Maria P. Rada

,

Dan Mihu