eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2010
vol. 35
 
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abstract:

Clinical immunology
The effect of enteral immune-enhancing diet (immunonutrition) on the apoptotic signaling pathways of peripheral blood lymphocytes in patients after pancreatic cancer surgery

Robert Słotwiński
,
Waldemar L. Olszewski
,
Maciej Słodkowski
,
Gustaw Lech
,
Marzanna Zaleska
,
Sylwia Kędziora
,
Sylwia M. Słotwińska
,
Gabriela Gulak
,
Wojciech I. Krasnodębski
,
Zdzisław Wójcik

Centr Eur J Immunol 2010; 35 (2): 90-93
Online publish date: 2010/05/10
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Malnutrition results in disorders of programmed cell death influencing the patients susceptibility to infections after major surgery. The preoperative nutrition is a promising way of improving outcome after pancreatic surgery. The purpose of our study was to investigate the influence of enteral nutrition on the changes of apoptotic signaling pathways. The randomized studies were performed in patients operated on for pancreatic cancer receiving standard or enteral immunonutrition. The expressions of Fas/CD95 and TNFRI/CD120a in lymphocytes were assessed by flow cytometry before and on day 1, 3 and 7 after surgery. In comparison to the standard nutrition, the preoperative immunonutrition significantly increased the percentage of CD95 and TNFRI positive lymphocytes after surgery. In conclusion, our findings suggest the up-regulation of proapoptotic signaling systems in lymphocytes of malnourished patients receiving immunonutrition after pancreatic cancer surgery. These changes in apoptotic signaling pathways proteins after immunonutrition may increase lymphocytes dysfunction.
keywords:

apoptosis, pancreatic cancer surgery, immunonutrition
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