eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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3/2021
vol. 16
 
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abstract:
Original paper

Clinical importance of serum CEA and CA-19-9 levels in oesophagogastric junction adenocarcinomas

Ozlem Zeliha Sert
1
,
Hilmi Bozkurt
2
,
Tolga Olmez
3
,
Emre Aray
4
,
Orhan Uzun
5
,
Selcuk Gulmez
5
,
Aziz Serkan Senger
5
,
Mustafa Duman
5
,
Erdal Polat
5

  1. Department of General Surgery, University of Health Sciences, Haydarpasa Education and Research Hospital, Istanbul, Turkey
  2. Department of General Surgery, University of Health Sciences, Haseki Education and Research Hospital, Istanbul, Turkey
  3. Department of Gastrointestinal Surgery, University of Health Sciences, Adana City Education and Research Hospital, Adana, Turkey
  4. Department of General Surgery, University of Health Sciences, Kutahya Evliya Celebi High Education and Research Hospital, Kutahya, Turkey
  5. Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu High Education and Research Hospital, Istanbul, Turkey
Gastroenterology Rev 2021; 16 (3): 240–247
DOI: https://doi.org/10.5114/pg.2020.101911
Online publish date: 2020/12/17
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Introduction
In recent years, the incidence of gastroesophageal junction tumors has increased rapidly in worldwide.

Aim
To evaluate pretreatment serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in oesophagogastric junction (OGJ) adenocarcinomas regarding clinicopathologic characteristics and overall survival.

Material and methods
Patients undergoing curative surgery diagnosed with OGJ adenocarcinoma in the gastrointestinal surgery clinic between 2007 and 2019 were included in the study retrospectively. Kaplan Meier and Log Rank tests were performed in survival analyses. Logistic regression analysis was performed to state the independent variables affecting survival.

Results
The mean age of the 70 patients included in the study was 59.78 ±10.49 (31–76) years. Serum CEA and CA 19-9 were high in 19 (27.1%) patients. CEA ≥ 5 ng/ml was found to be statistically significant in patients receiving neoadjuvant chemotherapy (NAC) and in patients with a high number of positive lymph nodes (N +) (p = 0.041 and p = 0.042, respectively). CA 19-9 positivity was statistically higher in patients with lymphovascular invasion (LVI) and diabetes mellitus (DM) (p = 0.042 and p = 0.012, respectively). The age and N+ findings of the patients in the CA 19-9-positive group were statistically significant compared to the patients in the CA 19-9-negative group (p = 0.039 and p = 0.007, respectively). Overall survival rates of 1–3 and 5 years were statistically significantly lower in patients who were CA 19-9 positive (p = 0.016). For patients in whom both tumour markers were positive, the N+ mean value was statistically significantly higher (p = 0.001).

Conclusions
In our study, a significant relationship was found in terms of overall survival and serum CA 19-9 in OGJ adenocarcinoma, and it was associated with both tumour markers being positive and the mean N+ value.

keywords:

adenocarcinoma, oesophagogastric junction, prognosis, survival, tumour markers
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