eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2012
vol. 63
 
Share:
Send email
Share:
abstract:

Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer

Cheng-Jeng Tai
,
Chun-Chao Chang
,
Ming-Chung Jiang
,
Chung-Min Yeh
,
Tzu-Cheng Su
,
Pei-Ru Wu
,
Chih-Jung Chen
,
Kun-Tu Yeh
,
Shu-Hui Lin
,
Hung-Chang Chen

POL J PATHOL 2012; 2: 93-100
Online publish date: 2012/08/03
View full text Get citation
 
The Ras-ERK pathway is frequently up-regulated in colorectal cancer. We analyzed the clinical-pathological correlation of K-Ras mutation and phospho-ERK expression in colorectal cancer. K-Ras mutations were detected in only 32.5% (41/126) of the colorectal cancer cases, while all cancers were positive for phospho-ERK staining. Colorectal cancer with wild-typeK-Ras and low phospho-ERK expression had a significantly higher survival rate (log-rank P = 0.04). There were 9 cases of K-Ras mutation/low phospho-ERK diseases; 88.9% (8/9) of them were stage III/IV diseases. High phospho-ERK expression was associated with a high stage and T status of the cancer, yet combined K-Ras mutation/phospho-ERK expression analysis further increased the efficiency of colorectal cancer prognosis. Our results demonstrate that Ras-ERK pathway correlated closely with colorectal cancer progression. Moreover, although colorectal cancer with K-Ras mutations has a more aggressive phenotype; the mutation rate is not very high. Phospho-ERK may be a useful marker in combination with K-Ras for improving the prognosis of colorectal cancer.
keywords:

colorectal cancer, ERK, mutation, phosphorylation, Ras
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.