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ISSN: 1233-9687
Polish Journal of Pathology
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1/2020
vol. 71
 
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abstract:
Original paper

Clinical significance of PON1 L55M, Q192R and I102V polymorphisms and their association with prostate cancer risk in Polish men

Marta Heise
1
,
Piotr Jarzemski
2
,
Aneta Bąk
1
,
Anna Junkiert-Czarnecka
1
,
Maria Pilarska-Deltow
1
,
Maciej Borysiak
2
,
Olga Haus
1

  1. Department of Clinical Genetics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  2. Piotr Jarzemski
Pol J Pathol 2020; 71 (1): 55-61
DOI: https://doi.org/10.5114/pjp.2020.95416
Online publish date: 2020/05/20
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We tested the association between PON1 L55M, Q192R and I102V polymorphic variants and PC risk in Polish men. DNA from 110 consecutive, newly diagnosed patients hospitalized because of PC and DNA from 110 men – volunteers, healthy at the time of the study. PCR-RFLP method. In our study the average age at PC diagnosis of 55MM genotype carriers from families fulfilling Hereditary Prostate Criteria (HPC) was statistically significantly lower (by 7 years) than the average age at the disease diagnosis of 55MM carriers from families without HPC (54.6 ±6.7 vs. 61.9 ±5.4, respectively, p = 0.03). The probability of 5-year survival for the 55MM carriers was 81.3%, compared to 95.7% for non-carriers (p = 0.08, tendency). This is the first study in Polish men evaluating the impact of PON1 genetic polymorphisms on prostate cancer development and its clinical course. PON1 55MM variant may be probably associated with younger age at PC onset in men from families with HPC and with a shorter survival. However, more extensive studies on a larger number of PC patients, possibly from various populations, are necessary to confirm, and extend our findings.
keywords:

prostate cancer; PON1 L55M, Q192R and I102V polymorphisms, predisposition, clinical characteristics
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