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ISSN: 1233-9687
Polish Journal of Pathology
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4/2011
vol. 62
 
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abstract:

Clinico-morphological parameters affecting survival of patients with advanced cervical cancer

Małgorzata Klimek
,
Anna Kruczak
,
Janusz Ryś
,
Katarzyna Mularz
,
Krzysztof Halaszka
,
Marcin Przewoźnik
,
Julia Moskal
,
Andrzej Sokołowski
,
Krzysztof Urbański

POL J PATHOL 2011; 3: 250-256
Online publish date: 2012/01/10
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The aim of the study was to investigate the prognostic significance of selected clinico-morphological parameters including Ki-67 antigen expression and microvessel density. The data of 122 patients with squamous cell carcinoma, FIGO stages IB-IIIB and treated with radiochemotherapy and brachytherapy were studied. Significant prognostic factors for disease-free survival in univariate analysis were the FIGO stage and the presence of atypical mitoses in carcinoma cells. Multivariate Cox analysis confirmed prognostic significance of the FIGO stage and Ki-67 expression with regard to disease-free survival. With regard to overall survival, the most important prognostic factor was Ki-67 antigen expression. The data concerning the pretreatment status of these parameters may be helpful in clinical practice.
keywords:

cervical cancer, radiochemotherapy, histopathology, Ki-67, MVD
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