1. Mattiuzzi C, Sanchis-Gomar F, Lippi G. Concise update on colorectal cancer epidemiology. Ann Transl Med 2019; 7: 609. DOI: 10.21037/atm.2019.07.91.
2.
Xie YH, Chen YX, Fang JY. Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther 2020; 5: 22. DOI: 10.1038/s41392-020-0116-z.
3.
Adam R, Haller DG, Poston G, et al. Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer – an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009. Ann Oncol 2010; 21: 1579-1584.
4.
Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature 2013; 501: 328-337.
5.
Bradshaw A, Wickremsekera A, Tan ST, et al. Cancer stem cell hierarchy in glioblastoma multiforme. Front Surg 2016; 3: 21. DOI: 10.3389/fsurg.2016.00021.
6.
Shipitsin M, Polyak K. The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab Invest 2008; 88: 459-463.
7.
Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med 2006; 355: 1253-1261.
8.
Chen C, Liu Y, Liu Y, Zheng P. The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle 2009; 8: 1158-1160.
9.
Rehman J. Empowering self-renewal and differentiation: the role of mitochondria in stem cells. J Mol Med (Berl) 2010; 88: 981-986.
10.
Kim TI. Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer. World J Gastroenterol 2014; 20: 3835-3846.
11.
Burkert J, Wright NA, Alison MR. Stem cells and cancer: an intimate relationship. J Pathol 2006; 209: 287-297.
12.
Ram R, Brasch HD, Dunne JC, et al. The identification of three cancer stem cell subpopulations within moderately differentiated lip squamous cell carcinoma. Front Surg 2017; 4: 12. DOI: 10.3389/fsurg.2017.00012.
13.
Featherston T, Yu HH, Dunne JC, et al. Cancer stem cells in moderately differentiated buccal mucosal squamous cell carcinoma express components of the renin–angiotensin system. Front Surg 2016; 3: 52. DOI: 10.3389/fsurg.2016.00052.
14.
Itinteang T, Dunne JC, Chibnall AM, et al. Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma express components of the renin–angiotensin system. J Clin Pathol 2016; 69: 942-945.
15.
Van Riggelen J, Yetil A, Felsher DW. MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 2010; 10: 301-309.
16.
Dang CV. MYC on the path to cancer. Cell 2012; 149: 22-35.
17.
O'Hagan RC, Ohh M, David G, et al. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev 2000; 14: 2185-2191.
18.
Strippoli A, Cocomazzi A, Basso M, et al. c-MYC expression is a possible keystone in the colorectal cancer resistance to EGFR inhibitors. Cancers (Basel) 2020; 12: 638. DOI: 10.3390/ cancers12030638.
19.
Lee KS, Kwak Y, Nam KH, et al. c-MYC copy-number gain is an independent prognostic factor in patients with colorectal cancer. PLoS One 2015; 10: e0139727. DOI: 10.1371/journal.pone.0139727.
20.
Kakisako KE, Miyahara MA, Uchino SH, et al. Prognostic significance of c-myc mRNA expression assessed by semi-quantitative RT-PCR in patients with colorectal cancer. Oncol Rep 1998; 5: 441-446.
21.
Böckelman C, Koskensalo S, Hagström J, et al. CIP2A overexpression is associated with c-Myc expression in colorectal cancer. Cancer Biol Ther 2012; 13: 289-295.
22.
Toon CW, Chou A, Clarkson A, et al. Immunohistochemistry for myc predicts survival in colorectal cancer. PLoS One 2014; 9: e87456. DOI: 10.1371/journal.pone.0087456.
23.
Smith DR, Myint T, Goh HS. Over-expression of the c-myc proto-oncogene in colorectal carcinoma. Br J Cancer 1993; 68: 407-413.
24.
He WL, Weng XT, Wang JL, et al. Association between c-Myc and colorectal cancer prognosis: a meta-analysis. Front Physiol 2018; 9: 1549. DOI: 10.3389/fphys.2018.01549.
25.
Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-322. DOI: 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9.
26.
Felthaus O, Ettl T, Gosau M, et al. Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines. Biochem Biophys Res Commun 2011; 407: 28-33. DOI: 10.1016/j.bbrc. 2011.02.084.
27.
Yoshida GJ, Saya H. Therapeutic strategies targeting cancer stem cells. Cancer Sci 2016; 107: 5-11.
28.
Petrelli F, Viale G, Cabiddu M, Barni S. Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients. Breast Cancer Res Treat 2015; 153: 477-491.
29.
Abubakar M, Orr N, Daley F, et al. Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups. Breast Cancer Res 2016; 18: 104. DOI: 10.1186/s13058-016-0765-6.
30.
Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002; 12: 432-438.
31.
Zhou H, Hu YU, Wang W, et al. Expression of Oct 4 is significantly associated with the development and prognosis of colorectal cancer. Oncol Lett 2015; 10: 691-696.
32.
Moharil RB, Dive A, Khandekar S, Bodhade A. Cancer stem cells: an insight. J Oral Maxillof Pathol 2017; 21: 463. DOI: 10.4103/jomfp.JOMFP_132_16.
33.
Liu FS, Hsieh YT, Chen JT, et al. FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia. Gynecol Oncol 2001; 82: 283-290.
34.
Voutsadakis IA. The pluripotency network in colorectal cancer pathogenesis and prognosis: an update. Biomark Med 2018; 12: 653-665.
35.
Dai X, Ge J, Wang X, et al. OCT4 regulates epithelial-mesenchymal transition and its knockdown inhibits colorectal cancer cell migration and invasion. Oncol Rep 2013; 29: 155-160.
36.
Talebi A, Kianersi K, Beiraghdar M. Comparison of gene expression of SOX2 and OCT4 in normal tissue, polyps, and colon adenocarcinoma using immunohistochemical staining. Adv Biomed Res 2015; 4: 234. DOI: 10.4103/2277-9175.167958.
37.
Gwak JM, Kim M, Kim HJ, et al. Expression of embryonal stem cell transcription factors in breast cancer: Oct4 as an indicator for poor clinical outcome and tamoxifen resistance. Oncotarget 2017; 8: 36305-36318.
38.
Cheng CC, Shi LH, Wang XJ, et al. Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066. Int J Oncol 2018; 53: 339-348.
39.
Lüscher B, Larsson LG. The basic region/helix–loop–helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation. Oncogene 1999; 18: 2955-2966.
40.
Türk Hematoloji Derneği, Klinisyen-Patolog Ortak Lenfoma Kursu, 6-7 Mart 2004, Grand Cevahir Otel, İstanbul.
41.
Luo ZW, Zhu MG, Zhang ZQ, et al. Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis. BMC Cancer 2019; 19: 123. DOI: 10.1186/s12885-019-5324-y.
42.
Shin IY, Sung NY, Lee YS, et al. The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67. Gut Liver 2014; 8: 13-23.
43.
Reimers MS, Zeestraten EC, van Alphen TC, et al. Combined analysis of biomarkers of proliferation and apoptosis in colon cancer: an immunohistochemistry-based study using tissue microarray. Int J Colorectal Dis 2014; 29: 1043-1052.
44.
Melling N, Kowitz CM, Simon R, et al. High Ki67 expression is an independent good prognostic marker in colorectal cancer. J Clin Pathol 2016; 69: 209-214.
45.
Li L, Bhatia R. Stem cell quiescence. Clin Cancer Res 2011; 17: 4936-4941.
46.
Cheung TH, Rando TA. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol 2013; 14: 329-340.
47.
Zhou Y, Xia L, Wang H, et al. Cancer stem cells in progression of colorectal cancer. Oncotarget 2018; 9: 33403-33415.