Close relationship between TAZhigh/SOX2high co-localization and metastasis in oral squamous cell carcinoma

Olga Stasikowska-Kanicka; Marta Woskowicz; Karolina Ulewicz; Marian Danilewicz; Małgorzata Wągrowska-Danilewicz

doi:10.5114/pjp.2021.111773

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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3/2021
vol. 72

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abstract:

Original paper

Close relationship between TAZhigh/SOX2high co-localization and metastasis in oral squamous cell carcinoma

Olga Stasikowska-Kanicka

¹

,

Marta Woskowicz

²

,

Karolina Ulewicz

³

,

Marian Danilewicz

⁴

,

Małgorzata Wągrowska-Danilewicz

⁴

Department of Diagnostic Techniques in Pathomorphology, Chair of Oncology, Medical University of Lodz, Poland
Department of Pathomorphology, Chair of Oncology, Medical University of Lodz, Poland
Department of Diagnostic Techniques in Pathomorphology, Chair of Oncology, Medical University of Lodz (student), Poland
The Central Clinical Hospital of the Medical University of Lodz, Poland

Pol J Pathol 2021; 72 (3): 229-236

DOI: https://doi.org/10.5114/pjp.2021.111773

Online publish date: 2022/01/19

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There is growing evidence which indicates that the development and the biological features of cancer such as the invasion, metastases and recurrence are related to the presence and behavior of the cancer stem cells (CSC). However, the regulatory mechanisms underlying CSCs-specific properties are poorly determined, the Hippo pathway has emerged as a fundamental regulator underlying CSCs stemness.

Immunohistochemical method was used to examine the immunoexpression of SOX2, TAZ and α-SMA in oral squamous cells carcinomas: with metastases –

OSCC M+ (n = 42), and without metastases – OSCC M– (n = 44), and 17 control cases.

The immunoexpression of SOX2, TAZ and α-SMA was significantly increased in both group of OSCC in comparison to control groups. Moreover, significantly increased TAZ and α-SMA immunoexpression were found in OSCC M+ compared to OSCC M-. In OSCC M+ and OSCC M- groups there were statistically significant correlations between the immunoexpression of TAZ vs SOX2 (r = 0.56, p < 0.001; r = 0.33, p < 0.03 respectively), and TAZ vs α-SMA (r = 0.64, p < 0.001; r = 0.67, p < 0.001 respectively). Moreover, there was statistically significant association between TAZ^high/SOX2^high coexistent immunoexpression and the presence of metastases (p < 0.007).

Our results may suggest that SOX2 and TAZ could potentially cooperate and contribute to process of metastasis, especially in cases with TAZ^high/SOX2^high expression.

keywords:

Close relationship between TAZhigh/SOX2high co-localization and metastasis in oral squamous cell carcinoma

Olga Stasikowska-Kanicka 1 , Marta Woskowicz 2 , Karolina Ulewicz 3 , Marian Danilewicz 4 , Małgorzata Wągrowska-Danilewicz 4

TAZ, SOX2, oral cancer, metastases, CSC

Olga Stasikowska-Kanicka

¹

,

Marta Woskowicz

²

,

Karolina Ulewicz

³

,

Marian Danilewicz

⁴

,

Małgorzata Wągrowska-Danilewicz

⁴