Colorectal cancer in the course of familial adenomatous polyposis:
natural history and treatment methods

Agata Gronowska; Stanisław Głuszek; Jacek Bicki; Jarosław Matykiewicz

doi:10.5114/ms.2020.102325

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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abstract:

Review paper

Colorectal cancer in the course of familial adenomatous polyposis: natural history and treatment methods

Agata M. Gronowska

¹

,

Stanisław Głuszek

^{1, 2, 3}

,

Jacek Bicki

^{1, 4}

,

Jarosław Matykiewicz

^{3, 4}

Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland
Department of Clinic General Oncological and Endocrinological Surgery, Regional Hospital, Kielce, Poland
Department of Surgical Oncology, Holy Cross Cancer Center, Kielce, Poland
Collegium Medicum, Jan Kochanowski University, Kielce, Poland

Medical Studies/Studia Medyczne 2020; 36 (4): 303–309

DOI: https://doi.org/10.5114/ms.2020.102325

Online publish date: 2020/12/31

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Familial adenomatous polyposis (FAP) is a group of diseases, mostly caused by an APC suppressor gene mutation inherited in an autosomal dominant pattern. It results in numerous adenomas formed in the epithelium of the large intestine leading to colorectal cancer in 100% of cases, with the mean age of 39, and a high risk of other fatal neoplasms. There is no causative treatment possible. Total colectomy performed at the right time is the only way to prevent the individual from developing colorectal cancer. The aim of this study was to present the diagnostic performance and treatment methods of FAP. Fast diagnosis and strict surveillance of patients and their families are the most important for effective treatment.

keywords:

Colorectal cancer in the course of familial adenomatous polyposis: natural history and treatment methods

Agata M. Gronowska 1 , Stanisław Głuszek 1, 2, 3 , Jacek Bicki 1, 4 , Jarosław Matykiewicz 3, 4

colorectal cancer, familial adenomatous polyposis, familial polyposis coli, APC gene mutation

Agata M. Gronowska

¹

,

Stanisław Głuszek

^{1, 2, 3}

,

Jacek Bicki

^{1, 4}

,

Jarosław Matykiewicz

^{3, 4}