eISSN: 1731-2515
ISSN: 0209-1712
Anestezjologia Intensywna Terapia
Bieżący numer Archiwum O czasopiśmie Rada naukowa Recenzenci Prenumerata Kontakt Zasady publikacji prac
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
2/2021
vol. 53
 
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Artykuł oryginalny

Combination of propofol and nasal sufentanil or intravenous midazolam for colonoscopy: a comparative study

Tulin Akarsu Ayazoglu
1
,
Sinan Uzman
2

  1. Alaattin Keykubat University, Turkey
  2. Health Sciences University, Haseki Training and Research Hospital, Turkey
Anestezjologia Intensywna Terapia 2021; 53, 2: 146–152
Data publikacji online: 2021/07/01
Pełna treść artykułu Pobierz cytowanie
 


Introduction
The aim of the study was to compare and evaluate the side effects (SEs) and sedation characteristics of synergistic sedation with doses of 0.25 μg kg-1 or 0.5 μg kg-1 intranasal (IN) sufentanil, and intravenous (IV) midazolam during propofol-based sedation in patients undergoing colonoscopy.

Material and methods
This was a prospective, randomized, double-blind study. The patients were randomly allocated into one of 3 groups: group I (n = 33) – sufentanil IN 0.5 μg kg–1; group II (n = 33) – sufentanil IN 0.25 μg kg-1; and group III (n = 33) – IN 0.9% NaCl (placebo) and IV 0.04 mg kg-1 midazolam. After 15 minutes, all patients received 0.5 mg kg-1 propofol intravenously. Cardiorespiratory side effects and sedation characteristics were compared.

Results
The propofol consumption in group III was significantly higher than in group I and II (P < 0.001). Spontaneous eye opening time was significantly longer in group III than in group I and II ( < 0.001). The patients in group III had significantly longer recovery times than patients in group I and II (P < 0.0001). Hypotension and bradycardia were not encountered during the study. The incidence of hypoxaemia was significantly greater in group III compared to other groups (P < 0.001). Pain control and endoscopist satisfaction was significantly better for group I and II than for group III (P < 0.001).

Conclusions
Synergistic sedation can be achieved safely and effectively by the combination of propofol and IN sufentanil or IV midazolam for colonoscopy. However, IN sufentanil can be considered as a reasonable alternative to IV midazolam due to less respiratory depression, and better pain control and endoscopist satisfaction.

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