Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes

Ahmed Al Gohary; Amany Elyamany; Dina Abdalla; Ahmed Abolfadl

doi:10.5114/ceh.2020.99529

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological changes

Ahmed Al Gohary

¹

,

Amany Elyamany

¹

,

Dina Abdalla

¹

,

Ahmed Abolfadl

¹

Faculty of Medicine, Alexandria University, Alexandria, Egypt

Clin Exp HEPATOL 2020; 6, 3: 275–281

DOI: https://doi.org/10.5114/ceh.2020.99529

Online publish date: 2020/09/30

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AMA

Al Gohary A, Elyamany A, Abdalla D, Abolfadl A. Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes. Clinical and Experimental Hepatology. 2020;6(3):275-281. doi:10.5114/ceh.2020.99529.

APA

Al Gohary, A., Elyamany, A., Abdalla, D.,  & Abolfadl, A. (2020). Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes. Clinical and Experimental Hepatology, 6(3), 275-281. https://doi.org/10.5114/ceh.2020.99529

Chicago

Al Gohary, Ahmed, Amany Elyamany, Dina Abdalla,  and Ahmed Abolfadl. 2020. "Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes". Clinical and Experimental Hepatology 6 (3): 275-281. doi:10.5114/ceh.2020.99529.

Harvard

Al Gohary, A., Elyamany, A., Abdalla, D.,  and Abolfadl, A. (2020). Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes. Clinical and Experimental Hepatology, 6(3), pp.275-281. https://doi.org/10.5114/ceh.2020.99529

MLA

Al Gohary, Ahmed et al. "Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes." Clinical and Experimental Hepatology, vol. 6, no. 3, 2020, pp. 275-281. doi:10.5114/ceh.2020.99529.

Vancouver

Al Gohary A, Elyamany A, Abdalla D, Abolfadl A. Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological
changes. Clinical and Experimental Hepatology. 2020;6(3):275-281. doi:10.5114/ceh.2020.99529.

PlumX metrics:

Introduction
To assess the degree of liver and spleen stiffness in chronic hepatitis C virus (HCV) patients co-infected with schistosomiasis, and chronic HCV mono-infected patients.

Material and methods
The present study was conducted on 50 Egyptian chronic HCV patients, categorized into two groups: group A (25 patients with chronic HCV mono-infection) and group B (25 patients with chronic HCV and schistosomiasis coinfection). Also, 25 age- and sex-matched healthy subjects with no evidence of liver disease were included in the study as a control group. Stage of fibrosis was assessed invasively by histopathological examination of liver biopsies (patients only) and non-invasively by acoustic radiation force impulse imaging (ARFI) (all subjects).

Results
ARFI of liver (ARFI L) and ARFI of spleen (ARFI S) in group A patients who had significant fibrosis were 1.82 ±0.24 and 2.72 ±0.26, respectively, while in group B, ARFI L and ARFI S in patients with significant fibrosis was 1.99 ±0.53 and 3.10 ±0.57, respectively.

Conclusions
The current study demonstrated insignificantly higher values of liver stiffness and significantly higher values of spleen stiffness assessed by ARFI in patients co-infected with HCV and schistosomiasis than mono-infected with HCV.

keywords:

Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological changes

Ahmed Al Gohary 1 , Amany Elyamany 1 , Dina Abdalla 1 , Ahmed Abolfadl 1

elasticity, stiffness, hepatitis C virus, schistosomiasis

Ahmed Al Gohary

¹

,

Amany Elyamany

¹

,

Dina Abdalla

¹

,

Ahmed Abolfadl

¹