Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol

Jadwiga Dudkiewicz-Wilczyńska; Agnieszka Grabowska; Iza Książek; Karolina Sitarz; Piotr Suchocki; Elżbieta Anuszewska

doi:10.5114/wo.2014.40558

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2014
vol. 18

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abstract:

Original paper

Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol

Jadwiga Dudkiewicz-Wilczyńska

,

Agnieszka Grabowska

,

Iza Książek

,

Karolina Sitarz

,

Piotr Suchocki

,

Elżbieta Anuszewska

Contemp Oncol (Pozn) 2014; 18 (2): 90–94

DOI: https://doi.org/10.5114/wo.2014.40558

Online publish date: 2014/06/03

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AMA

Dudkiewicz-Wilczyńska J, Grabowska A, Książek I, Sitarz K, Suchocki P, Anuszewska E. Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol. Contemporary Oncology/Współczesna Onkologia. 2014;18(2):90-94. doi:10.5114/wo.2014.40558.

APA

Dudkiewicz-Wilczyńska, J., Grabowska, A., Książek, I., Sitarz, K., Suchocki, P.,  & Anuszewska, E. (2014). Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol. Contemporary Oncology/Współczesna Onkologia, 18(2), 90-94. https://doi.org/10.5114/wo.2014.40558

Chicago

Dudkiewicz-Wilczyńska, Jadwiga, Agnieszka Grabowska, Iza Książek, Karolina Sitarz, Piotr Suchocki,  and Elżbieta Anuszewska. 2014. "Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol". Contemporary Oncology/Współczesna Onkologia 18 (2): 90-94. doi:10.5114/wo.2014.40558.

Harvard

Dudkiewicz-Wilczyńska, J., Grabowska, A., Książek, I., Sitarz, K., Suchocki, P.,  and Anuszewska, E. (2014). Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol. Contemporary Oncology/Współczesna Onkologia, 18(2), pp.90-94. https://doi.org/10.5114/wo.2014.40558

MLA

Dudkiewicz-Wilczyńska, Jadwiga et al. "Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol." Contemporary Oncology/Współczesna Onkologia, vol. 18, no. 2, 2014, pp. 90-94. doi:10.5114/wo.2014.40558.

Vancouver

Dudkiewicz-Wilczyńska J, Grabowska A, Książek I, Sitarz K, Suchocki P, Anuszewska E. Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol. Contemporary Oncology/Współczesna Onkologia. 2014;18(2):90-94. doi:10.5114/wo.2014.40558.

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Aim of the study: Cellular resistance is strongly correlated with the risk of failure in doxorubicin (DOX) treatment, and the knowledge of the mechanisms of resistance and its possible modulation is still very limited.

Material and methods: In this study, we assessed the effect of 5% Selol and DOX on the expression of genes that affect cell proliferation in the resistant KB-V1 and sensitive HeLa cell lines, using RT2 ProfilerTM PCR Array matrix “Human Cancer Drug Resistance and Metabolism” (SABiosciences).

Results: We showed that HeLa and KB-V1 cell lines, characterised by varying susceptibility to DOX, have different genetic profiles as regards the studied genes. KB-V1 cells show overexpression of MYC and BCL2 genes, which encode proteins with anti apoptotic properties. Selol, when used in KB-V1 cells, reduced the expression of MYC and BCL2 genes, suggested as a new therapeutic target in the treatment of cancers resistant to cytostatic drugs.

keywords:

Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol

Jadwiga Dudkiewicz-Wilczyńska , Agnieszka Grabowska , Iza Książek , Karolina Sitarz , Piotr Suchocki , Elżbieta Anuszewska

Selol, doxorubicin, drug resistance, qRT-PCR, expression, genes

Jadwiga Dudkiewicz-Wilczyńska

,

Agnieszka Grabowska

,

Iza Książek

,

Karolina Sitarz

,

Piotr Suchocki

,

Elżbieta Anuszewska