eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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4/2019
vol. 14
 
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abstract:
Original paper

Comparison of three therapeutic interventions for chronic constipation in paediatric patients with cerebral palsy: a randomised clinical trial

Mohammad Hadi Imanieh
1
,
Mohammad Reza Golpayegan
2
,
Mostafa Sedighi
3
,
Kamal Ahmadi
4
,
Abbas Aghaie
5
,
Seyed Mohsen Dehghani
1
,
Gholamreza Yousefi
6

  1. Department of Paediatric Gastroenterology, Gastroenterohepatology Research Centre of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  2. Department of Paediatrics, Clinical Research Development Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. Department of Paediatric Neurology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. Department of Epidemiology, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. Department of Paediatrics Gastroenterology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Gastroenterology Rev 2019; 14 (4): 292–297
DOI: https://doi.org/10.5114/pg.2019.84872
Online publish date: 2019/05/08
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Introduction
Cerebral palsy (CP) is a permanent non-progressive movement disorder, which is due to brain injuries during brain development. Constipation is one of the prevalent conditions in children with CP that can adversely affect the psychological health, appetite, and overall health of these patients.

Aim
To compare three therapeutic methods in the treatment of chronic constipation in CP children.

Material and methods
In this randomised clinical trial (RCT), paediatric CP patients with chronic constipation were randomly divided into three groups (groups A, B, and C). Group A received polyethylene glycol (PEG), group B received PEG with Motilium, and group C received Motilium for 2 weeks. Motilium was administered at 0.2 mg/kg/dose and PEG at 0.5 g/kg/dose three times daily. To compare the therapeutic effect the McNemar test was used and a significance level of 0.05 was considered.

Results
The highest rate of improvement in chronic constipation was seen in group B and the lowest rate belonged to group C. Satisfactory response frequency was seen in 10 patients in group A (58.8%), 17 patients in group B (94.4%), and 1 patient in group C (6.6%); p < 0.001.

Conclusions
According to the findings, simultaneous use of PEG and Motilium had the best therapeutic effect for chronic constipation among CP children. However, Motilium alone was nearly ineffective, and PEG alone had a moderate therapeutic effect.

keywords:

cerebral palsy, chronic constipation, polyethylene glycol, Motilium
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